2'-Deoxyadenosine-5'-triphosphate trisodium
Based on 1 Customer Validation
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 54680-12-5
- Formula: C10H13N5Na3O12P3
- Molecular Weight:557.13
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Metabolism/Protease Compound Library
HY-L012
-
Natural Product Library
HY-L021
-
Anti-Cancer Compound Library
HY-L025
-
Human Endogenous Metabolite Compound Library
HY-L030
-
Anti-Aging Compound Library
HY-L034
-
Nucleotide Compound Library
HY-L044
-
Alkaloids Library
HY-L071
-
Food-Sourced Compound Library
HY-L094
-
Anti-Cancer Natural Product Library
HY-L107
-
Human Metabolite Library
HY-L123
-
Animal-Sourced Natural Product Library
HY-L157
-
Multi-Target Compound Library
HY-L176
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Nucleotide Metabolite Compound Library
HY-L234
Biological Activity
|
Human Endogenous Metabolite |
DNA Polymerase |
2'-Deoxyadenosine-5'-triphosphate (0.5 mM; 0-10 min) induces cytochrome C release in a swelling-independent manner in mouse liver mitochondria, an effect inhibited by Cyclosporin A (HY-B0579)[2].
2'-Deoxyadenosine-5'-triphosphate (400 μM, 16 h) stimulates bacterial biofilm formation in vitro and stimulates bacterial adherence to human epithelial cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 54680-12-5
-
Appearance Solid
-
Molecular Weight 557.13
-
Formula C10H13N5Na3O12P3
-
Color White to off-white
-
SMILES
O[C@H]([C@H](O1)CO[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])=O)C[C@@H]1N2C3=NC=NC(N)=C3N=C2
-
Synonyms
dATP trisodium
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 250 mg/mL (448.73 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8. [Content Brief]
[2]. Yang JC, Cortopassi GA. dATP causes specific release of cytochrome C from mitochondria. Biochem Biophys Res Commun. 1998 Sep 18;250(2):454-7. [Content Brief]
[3]. Katona K, et al. Deoxy-adenosine-monophosphate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cells. Cancer Lett. 2006 Apr 28;235(2):281-90. [Content Brief]
[4]. Xi C, Wu J. dATP/ATP, a multifunctional nucleotide, stimulates bacterial cell lysis, extracellular DNA release and biofilm development. PLoS One. 2010 Oct 14;5(10):e13355. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7949 mL | 8.9746 mL | 17.9491 mL | 44.8728 mL |
| 5 mM | 0.3590 mL | 1.7949 mL | 3.5898 mL | 8.9746 mL | |
| 10 mM | 0.1795 mL | 0.8975 mL | 1.7949 mL | 4.4873 mL | |
| 15 mM | 0.1197 mL | 0.5983 mL | 1.1966 mL | 2.9915 mL | |
| 20 mM | 0.0897 mL | 0.4487 mL | 0.8975 mL | 2.2436 mL | |
| 25 mM | 0.0718 mL | 0.3590 mL | 0.7180 mL | 1.7949 mL | |
| 30 mM | 0.0598 mL | 0.2992 mL | 0.5983 mL | 1.4958 mL | |
| 40 mM | 0.0449 mL | 0.2244 mL | 0.4487 mL | 1.1218 mL | |
| 50 mM | 0.0359 mL | 0.1795 mL | 0.3590 mL | 0.8975 mL | |
| 60 mM | 0.0299 mL | 0.1496 mL | 0.2992 mL | 0.7479 mL | |
| 80 mM | 0.0224 mL | 0.1122 mL | 0.2244 mL | 0.5609 mL | |
| 100 mM | 0.0179 mL | 0.0897 mL | 0.1795 mL | 0.4487 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
2'-Deoxyadenosine-5'-triphosphate trisodium Related Classifications
HY-136648A Related Classifications
Powered by Bioz