2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite DNA/RNA Synthesis
  4. 2'-Deoxyadenosine-5'-triphosphate

2'-Deoxyadenosine-5'-triphosphate  (Synonyms: dATP)

Cat. No.: HY-136648
Handling Instructions Technical Support

2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (2'-Deoxyadenosine-5'-triphosphate trisodium) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

2'-Deoxyadenosine-5'-triphosphate

2'-Deoxyadenosine-5'-triphosphate Chemical Structure

CAS No. : 1927-31-7

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2'-Deoxyadenosine-5'-triphosphate Related Antibodies

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Description

2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase[1].

IC50 & Target

DNA Polymerase

 

Human Endogenous Metabolite

 

In Vitro

2'-Deoxyadenosine-5'-triphosphate (dATP) (0.01-0.5 mM; 600 sec) induces dose-dependent mitochondrial permeability transition in isolated mouse liver mitochondria, with a half-maximal response at 0.03 mM, and this induction is sensitive to cyclosporin A but not z-VAD[2].
dATP is required for apoptosome assembly and subsequent procaspase-9 activation in cell-free extracts, a key step in the intrinsic apoptotic pathway[3].
dATP directly induces specific cytochrome c release from isolated mitochondria, initiating a key step in the intrinsic apoptotic pathway[3].
2'-Deoxyadenosine-5'-triphosphate (dATP) (400 μM; 2 h) increases Escherichia coli K-12 membrane-damaged attached cells by over 2-fold and total attached cells by ~1.6-fold, and (400 μM; 2 h in planktonic cultures or 16 h in biofilms) increases eDNA release by 48% in planktonic cells and 200% in biofilm matrices[4].
2'-Deoxyadenosine-5'-triphosphate (dATP) (400 μM; 60 min) increases Acinetobacter baumannii adherence to human bronchial epithelial NCI-H292 cells by 100-fold, from 1.6 × 104 to 8.79 × 105 CFU/cm2, and promotes bacterial aggregate formation[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2'-Deoxyadenosine-5'-triphosphate Related Antibodies
Clinical Trial
Molecular Weight

491.18

Formula

C10H16N5O12P3
CAS No.
SMILES

O[C@H]([C@H](O1)CO[P](O[P](O[P](O)(O)=O)(O)=O)(O)=O)C[C@@H]1N2C3=NC=NC(N)=C3N=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2'-Deoxyadenosine-5'-triphosphate Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Deoxyadenosine-5'-triphosphate1927-31-7dATPEndogenous MetaboliteDNA/RNA SynthesisInhibitorinhibitorinhibit

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