3,4-Dicaffeoylquinic acid (Synonyms: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B)

Name: 3,4-Dicaffeoylquinic acid
Brand: MedChemExpress
SKU: HY-N0057
Rating: 5.0 (8 reviews)

Cat. No.: HY-N0057 Purity: 98.15%: Data Sheet
COA

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3,4-Dicaffeoylquinic acid (3,4-Di-O-caffeoylquinic acid), naturally isolated from Laggera alata, has antioxidative, DNA protective, neuroprotective and hepatoprotective properties. 3,4-Dicaffeoylquinic acid exerts apoptosis-mediated cytotoxicity and α-glucosidase inhibitory effects. 3,4-Dicaffeoylquinic acid possesses a unique mechanism of anti-influenza viral activity, that is, enhancing viral clearance by increasing TRAIL.

For research use only. We do not sell to patients.

CAS No. : 14534-61-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Based on 8 publication(s) in Google Scholar

Other Forms of 3,4-Dicaffeoylquinic acid:

(E)-3,4-Dicaffeoylquinic acid Get quote
3,4-Dicaffeoylquinic acid (Standard) Get quote

8 Publications Citing Use of MCE 3,4-Dicaffeoylquinic acid

Cell Proliferation/Viability Assay

Bio/Physico-chemical Assay

: 3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Sep;4(9):1231-1248. [Abstract]; Quantification of SA-β-Gal assay of UV-B-irradiated IMR90 fibroblasts, treated with the indicated compounds (3,4-Dicaffeoylquinic acid (Dicaffeoylquinic acid), etc.) at 1 μM concentration or 10 μg/mL for HK.

: 3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Nov 14;13(1):210. [Abstract]; Examination of the inhibition capability of caffeine, CGA, isoCGA-A, isoCGA-B (3,4-Dicaffeoylquinic acid) (1-5 μM; 1 h), isoCGA-C, methylferulic acid and luteolin against the entry of wild-type SARS-CoV-2 on 293 T-ACE2 cells by Vpp (MOI = 0.1).

: 3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Nov 14;13(1):210. [Abstract]; Co-immunoprecipitation using 293 T cells expressing SARS-CoV-2 spike-HA and ACE2 to verify that 5 compounds can inhibit the binding of ACE2 and spike. After anti-HA pulldown, adding 5 compounds (3,4-Dicaffeoylquinic acid (IsoCGA-B), etc.) (100 μM; 1 h), ACE2, and spike antibodies were used to detect by immunoblotting.

: 3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Nov 14;13(1):210. [Abstract]; Validation of the ability of caffeine, CGA, isoCGA-A, isoCGA-B (3,4-Dicaffeoylquinic acid) (1h), and isoCGA-C at 0, 25, 50, 100, and 200 μM to repress TMPRSS2 activity using a cell-based TMPRSS2 enzyme activity assay.

: 3,4-Dicaffeoylquinic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2023 Nov 14;13(1):210. [Abstract]; Through Western blot to test 5 compounds (3,4-Dicaffeoylquinic acid (IsoCGA-B) (1 h), etc.) at 100 μM impact cleavage of SARS-CoV-2 S by TMPRSS2.

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	IC₅₀	>35 mM Compound: 3	Cytotoxicity against human Jurkat T cells Cytotoxicity against human Jurkat T cells	[PMID: 15921434]
Jurkat	IC₅₀	>35 μM/mL Compound: 3	Cytotoxicity against human Jurkat T cells Cytotoxicity against human Jurkat T cells	[PMID: 15921434]

In Vitro

3,4-Dicaffeoylquinic acid acts as a greater primary antioxidant than its methanol extract, by having higher ferric reducing activity (EC₅₀ 2.18 μg/ml), β-carotene bleaching activity (EC₅₀ 23.85 μg/ml) and DPPH scavenging activity (EC₅₀ 68.91 μg/ml). 3,4-Dicaffeoylquinic acid exhibits a remarkable dose-dependent inhibitory effect on NCI-H23 (human lung adenocarcinoma) cell lines (EC₅₀ 3.26 μg/ml) and is found to be apoptotic in nature based on a clear indication of DNA fragmentation. 3,4-Dicaffeoylquinic acid also displays a concentration-dependent α-glucosidase inhibition with EC₅₀ 241.80 μg/ml^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

516.45

Formula

C₂₅H₂₄O₁₂

CAS No.

14534-61-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@H](OC(/C=C/C3=CC=C(O)C(O)=C3)=O)[C@H](O)C1)O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (96.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9363 mL	9.6815 mL	19.3630 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.15%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (254 KB) HNMR (312 KB) LCMS (105 KB)

Handling Instructions (2659 KB)

References

[1]. Takemura T, et al. 3,4-Dicaffeoylquinic Acid, a Major Constituent of Brazilian Propolis, Increases TRAIL Expression and Extends the Lifetimes of Mice Infected with the Influenza A Virus. Evid Based Complement Alternat Med. 2012;2012:946867. [Content Brief]

[2]. Liu X, et al. Protective effect of isochlorogenic acid B on liver fibrosis in non-alcoholic steatohepatitis of mice. Basic Clin Pharmacol Toxicol. 2019;124(2):144-153. [Content Brief]

[3]. Ooi KL, et al. Cytotoxic, apoptotic and anti-α-glucosidase activities of 3,4-di-O-caffeoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of Elephantopus mollis Kunth. J Ethnopharmacol. 2011;135(3):685-695. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9363 mL	9.6815 mL	19.3630 mL	48.4074 mL
	5 mM	0.3873 mL	1.9363 mL	3.8726 mL	9.6815 mL
	10 mM	0.1936 mL	0.9681 mL	1.9363 mL	4.8407 mL
	15 mM	0.1291 mL	0.6454 mL	1.2909 mL	3.2272 mL
	20 mM	0.0968 mL	0.4841 mL	0.9681 mL	2.4204 mL
	25 mM	0.0775 mL	0.3873 mL	0.7745 mL	1.9363 mL
	30 mM	0.0645 mL	0.3227 mL	0.6454 mL	1.6136 mL
	40 mM	0.0484 mL	0.2420 mL	0.4841 mL	1.2102 mL
	50 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.9681 mL
	60 mM	0.0323 mL	0.1614 mL	0.3227 mL	0.8068 mL
	80 mM	0.0242 mL	0.1210 mL	0.2420 mL	0.6051 mL

3,4-Dicaffeoylquinic acid Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,4-Dicaffeoylquinic acid14534-61-33,4-Di-O-caffeoylquinic acid Isochlorogenic acid BGlycosidaseInfluenza VirusApoptosisEndogenous MetabolitenaturallyantioxidativeDNAprotectiveneuroprotectivehepatoprotectiveInhibitorinhibitorinhibit

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3,4-Dicaffeoylquinic acid (Synonyms: 3,4-Di-O-caffeoylquinic acid; Isochlorogenic acid B)

Customer Review

Other Forms of 3,4-Dicaffeoylquinic acid:

3,4-Dicaffeoylquinic acid Related Antibodies

8 Publications Citing Use of MCE 3,4-Dicaffeoylquinic acid

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

3,4-Dicaffeoylquinic acid Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

3,4-Dicaffeoylquinic acid Related Classifications

Keywords:

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