7-Methoxy-β-carboline-1-propionic acid

Cat. No.: HY-N7173: Ficha de datos Instrucciones de manejo
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7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia.

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7-Methoxy-β-carboline-1-propionic acid Estructura química

No. CAS : 137756-13-9

Tamaño		Stock
5 mg		Obtener un presupuesto	Estimated Time of Arrival: December 31
10 mg		Obtener un presupuesto	Estimated Time of Arrival: December 31

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This product is a controlled substance and not for sale in your territory.

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Descripciòn

7-Methoxy-β-carboline-1-propionic acid (compound 46) is a cytotoxic and antimalarial compound. 7-Methoxy-β-carboline-1-propionic acid can be extracted from the roots of Eurycoma longifolia^[1].

IC₅₀ & Target

Plasmodium

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	>20 μg/mL Compound: 7-methoxy-beta-carboline-1-propionicacid	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 14575431]
Calu-3	CC₅₀	>100 μM Compound: Table 1, R8C2	Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
HCT-8	CC₅₀	79 μM Compound: Table 1, R8C2	Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
HepG2	CC₅₀	>100 μM Compound: Table 1, R8C2	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
MCF7	ED₅₀	>20 μg/mL Compound: 7-methoxy-beta-carboline-1-propionicacid	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 14575431]
MRC5	CC₅₀	>100 μM Compound: Table 1, R8C2	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]
Vero	CC₅₀	>100 μM Compound: Table 1, R8C2	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay	[PMID: 36399766]

Peso molecular

270.28

Fòrmula

C₁₅H₁₄N₂O₃

No. CAS

137756-13-9

SMILES

O=C(O)CCC1=NC=CC2=C1NC3=C2C=CC(OC)=C3

Structure Classification

Alkaloids

Ketones, Aldehydes, Acids

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Kuo PC, et al. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorg Med Chem. 2004 Feb 1;12(3):537-44. [Content Brief]