1. Anti-infection
  2. Influenza Virus
  3. Amantadine hydrochloride

Amantadine hydrochloride (Synonyms: 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride)

Cat. No.: HY-B0402A Purity: >98.0%
Handling Instructions

Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.

For research use only. We do not sell to patients.

Amantadine hydrochloride Chemical Structure

Amantadine hydrochloride Chemical Structure

CAS No. : 665-66-7

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10 mM * 1  mL in Water USD 55 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug. Target: Influenza Virus Amantadine Hydrochloride is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. Amantadine Hydrochloride binding of M2, based on studies of a peptide representing the M2 transmembrane segment in dodecylphosphocholine micelles. Amantadine Hydrochloride competes with protons for binding to the deprotonated tetramer, thereby stabilizing the tetramer in a slightly altered conformation. This model accounts for the observed inhibition of proton flux by amantadine [1]. In contrast to most other described channel-blocking molecules, amantadine causes the channel gate of NMDA receptors to close more quickly. Amantadine Hydrochloride binding inhibits current flow through NMDA receptor channels but show that its main inhibitory action at pharmaceutically relevant concentrations results from stabilization of closed states of the channel [2].

Clinical Trial
Molecular Weight

187.71

Formula

C₁₀H₁₈ClN

CAS No.

665-66-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (532.74 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (266.37 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3274 mL 26.6368 mL 53.2737 mL
5 mM 1.0655 mL 5.3274 mL 10.6547 mL
10 mM 0.5327 mL 2.6637 mL 5.3274 mL
*Please refer to the solubility information to select the appropriate solvent.
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Keywords:

Amantadine1-Adamantanamine1-Adamantylamine1-AminoadamantaneInfluenza VirusInhibitorinhibitorinhibit

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Amantadine hydrochloride
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HY-B0402A
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