Cat. No.: HY-B0402A

Amantadine hydrochloride

(Synonyms: 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride)

11 Cited Publications

고객리뷰

Based on 11 publication(s) in Google Scholar

Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.0%
CAS No.: 665-66-7
화학식: C₁₀H₁₈ClN
분자량:187.71

보관:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

Amantadine hydrochloride Chemical Structure

CAS No.: 665-66-7

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (11)
용액&용해도
- In Vitro
- In Vivo
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

CDK2

Bcl-2

Bax

All Bcl-2 Family Isoforms :

All CDK Isoforms :

In Vitro

Amantadine hydrochloride (0-500 μM, 26 h) inhibits SARS-CoV-2 replication, with IC₅₀ concentrations between 83 and 119 μM^[4].
? Amantadine hydrochloride (0-100 μg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC?7721 cells^[6].
? Amantadine hydrochloride (0-75 μg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis^[6].
? ? Amantadine hydrochloride (0-75 μg/mL, 48 h) reduces the levels of the cell cycle?related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:

Vero E6 cells
Concentration:

500 µM, 100 µM, 20 µM, 4 µM, and 8 nM
Incubation Time:

26 h
Result:

Caused a concentration-dependent reduction (IC₅₀=83 µM) of viral nucleic acids in the supernatant 26 h after infection at 10-500 µM. Caused a concentration-dependent reduction (IC₅₀=119 µM) of viral nucleic acids in the cytosol 26 h after infection.

Cell Proliferation Assay^[6]

Cell Line:

Human HCC cell lines (HepG2 and SMMC-7721) and normal hepatocellular cells (L02 cells)
Concentration:

0, 1, 2, 5, 10, 25, 50 and 100 µg/mL
Incubation Time:

24, 48 and 72 h
Result:

Inhibited cellular proliferation in a time- and dose-dependent manner in HepG2 and SMMC-7721 cells.

Cell Cycle Analysis^[6]

Cell Line:

HepG2 and SMMC-7721 cells
Concentration:

0, 10, 25, 50 and 75 µg/mL
Incubation Time:

48 h
Result:

Significantly increased the population of HepG2 and SMMC-7721 cells in the G0/G1 phase in a dose-dependent manner, and significantly decreased the number of HepG2 cells in the S phase.

Apoptosis Analysis^[6]

Cell Line:

HepG2 and SMMC-7721 cells
Concentration:

0, 10, 25, 50 and 75 µg/mL
Incubation Time:

48 h
Result:

Markedly increased the percentage of apoptotic HepG2 and SMMC-7721 cells (early- and late-stage apoptosis) in a dose-dependent manner.

Western Blot Analysis^[6]

Cell Line:

HepG2 and SMMC-7721 cells
Concentration:

0, 10, 25, 50 and 75 µg/mL
Incubation Time:

48 h
Result:

Showed downregulation of cyclin D1, cyclin E and CDK2, and showed a decrease in Bcl-2 levels and an increase of Bax levels in HepG2 and SMMC-7721 cells.

RT-PCR^[6]

Cell Line:

HepG2 and SMMC-7721 cells
Concentration:

0, 10, 25, 50 and 75 µg/mL
Incubation Time:

48 h
Result:

Revealed an increase in Bax and decrease in Bcl-2 genes.

In Vivo

Amantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)^[5]
Dosage:

25 mg/kg
Administration:

IP, once daily for 3 days (the first dose at 15 min before surgery)
Result:

Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.

Chemical Information

CAS No. 665-66-7
Appearance Solid
분자량 187.71
화학식 C₁₀H₁₈ClN
Color White to off-white
SMILES

NC1(C2)C[C@@H]3C[C@@H](C[C@H]2C3)C1.Cl
Synonyms

1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride
선적

Room temperature in continental US; may vary elsewhere.

보관

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Publications (11)

All

Sort by:

Journal Impact Factor

Signal Transduct Target Ther

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. [Abstract]

2021 Mar 27;6(1):134. PMID: 33774649
Int J Nanomedicine

The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via Intranasal Route. [Abstract]

2019 Nov 27:14:9217-9234. PMID: 31819426
Emerg Microbes Infect

Efficient airborne transmission of influenza D virus in ferret models and serological evidence of human exposure in Northeast China. [Abstract]

2025 Dec;14(1):2564308. PMID: 41069204
Int J Mol Sci

Lycorine Inhibits Influenza Virus Replication by Affecting Nascent Nucleoporin Nup93 Synthesis. [Abstract]

2025 Jun 3;26(11):5358. PMID: 40508167
PLoS Pathog

Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]

2026 Jan 26;22(1):e1013903. PMID: 41587213
ACS Infect Dis

Development of a Universal Type A Influenza Viral RdRp-Induced Reporter System with Potential for Antiviral Drug Screening. [Abstract]

2025 Jun 13;11(6):1437-1447. PMID: 40421776
Virol J

Bisbenzylisoquinoline alkaloids inhibit influenza virus replication by disrupting endosomal acidification. [Abstract]

2025 Jun 4;22(1):181. PMID: 40468427
Open Forum Infect Dis

Toward Personalized Medicine: The Effect of Treatment of Chronic Enterovirus Diarrhea in an Immunocompromised Patient and the Correlation With In Vitro Models. [Abstract]

2025 Apr 10;12(5):ofaf212. PMID: 40302715
Chem Phys Lipids

Amantadine interactions with phase separated lipid membranes. [Abstract]

2024 Aug:262:105397. PMID: 38740276
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
bioRxiv

2026 Jun 10.

용액&용해도

In Vitro:

DMSO : 100 mg/mL (532.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (266.37 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.3274 mL

26.6368 mL

53.2737 mL

5 mM

1.0655 mL

5.3274 mL

10.6547 mL

10 mM

0.5327 mL

2.6637 mL

5.3274 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 6.88 mg/mL (36.65 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (779 KB)
- English - EN (779 KB)
- Français - FR (779 KB)
- Deutsch - DE (779 KB)
- Norwegian - NO (779 KB)
- Español - ES (779 KB)
- Swedish - SV (779 KB)
- Italian - IT (779 KB)
- Korean - KR (779 KB)
- Portuguese - PT (779 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. [Content Brief]

[2]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. [Content Brief]

[3]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [Content Brief]

[4]. Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. [Content Brief]

[5]. Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. [Content Brief]

[6]. Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	5.3274 mL	26.6368 mL	53.2737 mL	133.1842 mL
	5 mM	1.0655 mL	5.3274 mL	10.6547 mL	26.6368 mL
	10 mM	0.5327 mL	2.6637 mL	5.3274 mL	13.3184 mL
	15 mM	0.3552 mL	1.7758 mL	3.5516 mL	8.8789 mL
	20 mM	0.2664 mL	1.3318 mL	2.6637 mL	6.6592 mL
	25 mM	0.2131 mL	1.0655 mL	2.1309 mL	5.3274 mL
	30 mM	0.1776 mL	0.8879 mL	1.7758 mL	4.4395 mL
	40 mM	0.1332 mL	0.6659 mL	1.3318 mL	3.3296 mL
	50 mM	0.1065 mL	0.5327 mL	1.0655 mL	2.6637 mL
	60 mM	0.0888 mL	0.4439 mL	0.8879 mL	2.2197 mL
	80 mM	0.0666 mL	0.3330 mL	0.6659 mL	1.6648 mL
	100 mM	0.0533 mL	0.2664 mL	0.5327 mL	1.3318 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Amantadine hydrochloride

11 Cited Publications

100 mg 견적 받기

Subscribe to the

MedChemExpress

Newsletter

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Amantadine hydrochloride

Bioactive Compound Library Max

Bioactive Compound Library

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Antiviral Compound Library

CNS-Penetrant Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

NMPA-Approved Drug Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Breast Cancer Compound Library

Drug-Induced Liver Injury (DILI) Compound Library

Anti-Blood Cancer Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Mitochondria-Targeted Compound Library

Rare Diseases Drug Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Anti-Orthopoxvirus Compound Library

Cancer Stem Cells Compound Library

Off-patent Drug Library

Cell Death Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Mitophagy Compound Library

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Posttranslational Modification Library

FDA Kinase Inhibitor Library

High-Efficiency Gene Editing Compound Library

Publications Citing Use of MedChemExpress (MCE) Amantadine hydrochloride

All Bcl-2 Family Isoforms

All CDK Isoforms

Biological Activity

Chemical Information

Publications (11)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

Amantadine hydrochloride Related Classifications

HY-B0402A Related Classifications