1. Anti-infection
  2. Influenza Virus
  3. Amantadine hydrochloride

Amantadine hydrochloride (Synonyms: 1-Adamantanamine hydrochloride; 1-Adamantylamine hydrochloride; 1-Aminoadamantane hydrochloride)

Cat. No.: HY-B0402A Purity: >98.0%
Handling Instructions

Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug.

For research use only. We do not sell to patients.

Amantadine hydrochloride Chemical Structure

Amantadine hydrochloride Chemical Structure

CAS No. : 665-66-7

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 g USD 60 In-stock
Estimated Time of Arrival: December 31
10 g USD 84 In-stock
Estimated Time of Arrival: December 31
50 g USD 180 In-stock
Estimated Time of Arrival: December 31
> 100 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Amantadine hydrochloride

  • Biological Activity

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Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug. Target: Influenza Virus Amantadine Hydrochloride is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. Amantadine Hydrochloride binding of M2, based on studies of a peptide representing the M2 transmembrane segment in dodecylphosphocholine micelles. Amantadine Hydrochloride competes with protons for binding to the deprotonated tetramer, thereby stabilizing the tetramer in a slightly altered conformation. This model accounts for the observed inhibition of proton flux by amantadine [1]. In contrast to most other described channel-blocking molecules, amantadine causes the channel gate of NMDA receptors to close more quickly. Amantadine Hydrochloride binding inhibits current flow through NMDA receptor channels but show that its main inhibitory action at pharmaceutically relevant concentrations results from stabilization of closed states of the channel [2].

Clinical Trial
Molecular Weight







Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (532.74 mM; Need ultrasonic)

H2O : ≥ 50 mg/mL (266.37 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3274 mL 26.6368 mL 53.2737 mL
5 mM 1.0655 mL 5.3274 mL 10.6547 mL
10 mM 0.5327 mL 2.6637 mL 5.3274 mL
*Please refer to the solubility information to select the appropriate solvent.
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Amantadine1-Adamantanamine1-Adamantylamine1-AminoadamantaneInfluenza VirusInhibitorinhibitorinhibit

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