Amantadine sulfate
Based on 11 publication(s) in Google Scholar
Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research.
For research use only. We do not sell to patients.
- CAS No.: 31377-23-8
- Formula: C10H17N.1/2H2O4S
- Molecular Weight:200.18
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Amantadine sulfate
More- Signal Transduct Target Ther. 2021 Mar 27;6(1):134. [Abstract]
- Int J Nanomedicine. 2019 Nov 27;14:9217-9234. [Abstract]
- Emerg Microbes Infect. 2025 Dec;14(1):2564308. [Abstract]
- Int J Mol Sci. 2025 Jun 3;26(11):5358. [Abstract]
- PLoS Pathog. 2026 Jan 26;22(1):e1013903. [Abstract]
- ACS Infect Dis. 2025 Jun 13;11(6):1437-1447. [Abstract]
- Virol J. 2025 Jun 4;22(1):181. [Abstract]
- Open Forum Infect Dis. 2025 Apr 10;12(5):ofaf212. [Abstract]
- Chem Phys Lipids. 2024 May 11:262:105397. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- bioRxiv. 2026 Jun 10.
Biological Activity
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CDK2 |
Bcl-2 |
Bax |
Amantadine sulfate (0-500 µM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 µM[4].
Amantadine sulfate (0-100 µg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC‑7721 cells[6].
Amantadine sulfate (0-75 µg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis[6].
Amantadine sulfate (0-75 µg/mL, 48 h) reduces the levels of the cell cycle‑related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero E6 cells
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Concentration:500 µM, 100 µM, 20 µM, 4 µM, and 8 nM
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Incubation Time:26 h
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Result:Caused a concentration-dependent reduction (IC50=83 µM) of viral nucleic acids in the supernatant 26 h after infection at 10-500 µM. Caused a concentration-dependent reduction (IC50=119 µM) of viral nucleic acids in the cytosol 26 h after infection.
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Cell Line:Human HCC cell lines (HepG2 and SMMC-7721) and normal hepatocellular cells (L02 cells)
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Concentration:0, 1, 2, 5, 10, 25, 50 and 100 µg/mL
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Incubation Time:24, 48 and 72 h
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Result:Inhibited cellular proliferation in a time- and dose-dependent manner in HepG2 and SMMC-7721 cells.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:0, 10, 25, 50 and 75 µg/mL
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Incubation Time:48 h
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Result:Significantly increased the population of HepG2 and SMMC-7721 cells in the G0/G1 phase in a dose-dependent manner, and significantly decreased the number of HepG2 cells in the S phase.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:0, 10, 25, 50 and 75 µg/mL
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Incubation Time:48 h
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Result:Markedly increased the percentage of apoptotic HepG2 and SMMC-7721 cells (early- and late-stage apoptosis) in a dose-dependent manner.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:0, 10, 25, 50 and 75 µg/mL
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Incubation Time:48 h
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Result:Showed downregulation of cyclin D1, cyclin E and CDK2, and showed a decrease in Bcl-2 levels and an increase of Bax levels in HepG2 and SMMC-7721 cells.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:0, 10, 25, 50 and 75 µg/mL
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Incubation Time:48 h
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Result:Revealed an increase in Bax and decrease in Bcl-2 genes.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Fischer 344 rats (Four-month old, male, 290-330 g, 15 rats each group)[5]
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Dosage:25 mg/kg
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Administration:IP, once daily for 3 days (the first dose at 15 min before surgery)
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Result:Inhibited surgery induced neuroinflammation and learning and memory impairment, increased GDNF (glial cell line-derived neurotrophic factor) that was co-localized with glial fibrillary acidic protein (an astrocytic marker) in the hippocampus.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 31377-23-8
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Molecular Weight 200.18
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Formula C10H17N.1/2H2O4S
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SMILES
NC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.O=S(O)(O)=O.[1/2]
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Synonyms
1-Adamantanamine sulfate; 1-Aminoadamantane sulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (11)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. [Abstract]2021 Mar 27;6(1):134. PMID: 33774649 -
Int J Nanomedicine
The Optimization Design Of Lactoferrin Loaded HupA Nanoemulsion For Targeted Drug Transport Via Intranasal Route. [Abstract]2019 Nov 27;14:9217-9234. PMID: 31819426 -
Emerg Microbes Infect
Efficient airborne transmission of influenza D virus in ferret models and serological evidence of human exposure in Northeast China. [Abstract]2025 Dec;14(1):2564308. PMID: 41069204 -
Int J Mol Sci
Lycorine Inhibits Influenza Virus Replication by Affecting Nascent Nucleoporin Nup93 Synthesis. [Abstract]2025 Jun 3;26(11):5358. PMID: 40508167 -
PLoS Pathog
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [Abstract]2026 Jan 26;22(1):e1013903. PMID: 41587213 -
ACS Infect Dis
Development of a Universal Type A Influenza Viral RdRp-Induced Reporter System with Potential for Antiviral Drug Screening. [Abstract]2025 Jun 13;11(6):1437-1447. PMID: 40421776 -
Virol J
Bisbenzylisoquinoline alkaloids inhibit influenza virus replication by disrupting endosomal acidification. [Abstract]2025 Jun 4;22(1):181. PMID: 40468427 -
Open Forum Infect Dis
Toward Personalized Medicine: The Effect of Treatment of Chronic Enterovirus Diarrhea in an Immunocompromised Patient and the Correlation With In Vitro Models. [Abstract]2025 Apr 10;12(5):ofaf212. PMID: 40302715 -
Chem Phys Lipids
2024 May 11:262:105397. PMID: 38740276 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Purity & Documentation
References
[1]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. [Content Brief]
[2]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099. [Content Brief]
[3]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52. [Content Brief]
[4]. Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13(4):539. [Content Brief]
[5]. Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121(4):773-85. [Content Brief]
[6]. Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36(3):904-910. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amantadine sulfate Related Classifications
HY-B0402B Related Classifications
Powered by Bioz
- Amantadine
- 31377-23-8
- 1-Adamantanamine
- 1-Aminoadamantane
- Influenza Virus
- Orthopoxvirus
- SARS-CoV
- Apoptosis
- CDK
- Bcl-2 Family
- M2 proton channel
- antiviral
- Parkinson's disease
- Vero E6 cells
- antiviral drugs
- Covid-19
- SARS-CoV-2
- orthopoxvirus
- memory impairment
- Postoperative cognitive dysfunction
- POCD
- Neuroinflammation
- HCC cells
- HepG2
- SMMC 7721
- hepatitis C virus
- anticancer
- liver cancer
- Inhibitor
- inhibitor
- inhibit