BAY-876

Name: BAY-876
Brand: MedChemExpress
SKU: HY-100017
Rating: 5.0 (52 reviews)

製品番号: HY-100017 純度: 99.67%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC₅₀ of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 1799753-84-6

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 131	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 131	在庫あり	Estimated Time of Arrival: December 31
Solid
2 mg	$96	在庫あり	Estimated Time of Arrival: December 31
5 mg	$120	在庫あり	Estimated Time of Arrival: December 31
10 mg	$180	在庫あり	Estimated Time of Arrival: December 31
25 mg	$300	在庫あり	Estimated Time of Arrival: December 31
50 mg	$450	在庫あり	Estimated Time of Arrival: December 31
100 mg	$720	在庫あり	Estimated Time of Arrival: December 31
500 mg	$2160	在庫あり	Estimated Time of Arrival: December 31
1 g	$3456	在庫あり	Estimated Time of Arrival: December 31
5 g		お問い合わせ
10 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 52 publication(s) in Google Scholar

Other Forms of BAY-876:

BAY-876 (Standard) お問い合わせ

顧客検証

Flow Cytometry

Cell Proliferation/Viability Assay

: BAY-876 purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2025 Sep 2. [Abstract]; BLI reveals that BAY-876 (3.84 mg/kg; Intrathecally injected on days 3 and 7 post-xenograft) treatment decreases the incidence of MB metastasis in ONS76 intracisternal xenograft models. Images were taken 8 days post implantation.

: BAY-876 purchased from MedChemExpress. Usage Cited in: Nat Biomed Eng. 2025 Sep 2. [Abstract]; BLI reveals that BAY-876 (3.84 mg/kg; Intrathecally injected on days 3 and 7 post-xenograft) treatment decreases the incidence of MB metastasis in DAOY intracisternal xenograft models. Images were taken 8 days post implantation.

: BAY-876 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 19;15(1):9027. [Abstract]; Quantification of blood Ly6C^high and Ly6C^low monocytes from CX3CR1GFP mice treated with vehicle (n = 4) or 4.5 mg/kg/day BAY-876 (oral) for 4 days.

: BAY-876 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 19;15(1):9027. [Abstract]; Quantification of blood Ly6C^high monocyte viability after a 4-day treatment with vehicle (n = 4) or 4.5 mg/kg/day BAY-876 (oral) (n = 5) in C57BL6/J mice.

: BAY-876 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 19;15(1):9027. [Abstract]; Representative histograms (left) and quantitative results (right) show the difference in 2-NBDG signal in monocytes after 4 days of treatment with the vector (n=4) or 4.5 mg/kg/day BAY-876 (n=2).

: BAY-876 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 19;15(1):9027. [Abstract]; Quantification of bone marrow hematopoietic progenitors after acute vehicle or BAY-876 (4.5 mg/kg/day, oral) treatment.

: BAY-876 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 19;15(1):9027. [Abstract]; BAY-876 (0-6 mg/kg/day, oral) reduces monocyte count in a dose-dependent manner.

GLUT アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

GLUT1 GLUT2 GLUT3 GLUT4

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

GLUT1

2 nM (IC₅₀)

GLUT2

10.08 μM (IC₅₀)

GLUT3

1.67 μM (IC₅₀)

GLUT4

0.29 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	4809 nM Compound: 6; BAY-876	Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay Inhibition of GLUT3 in SLC2A1-deficient human DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay	[PMID: 32282207]
DLD-1	IC₅₀	50 nM Compound: 6; BAY-876	Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay Inhibition of GLUT1 in human wild-type DLD1 cells assessed as reduction in ATP level measured after 90 mins by Celltiter-glo luminescent assay	[PMID: 32282207]
HEK293	IC₅₀	>10 μM Compound: 118191391	Inhibition of the Glucose Transporter (GLUT3, SLC2A3) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A3 WT-OE cells Inhibition of the Glucose Transporter (GLUT3, SLC2A3) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A3 WT-OE cells	10.5281/zenodo.7360656
HEK293	IC₅₀	>10 μM Compound: 118191391	Inhibition of the Glucose Transporter (GLUT2, SLC2A2) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A2 WT-OE cells Inhibition of the Glucose Transporter (GLUT2, SLC2A2) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A2 WT-OE cells	10.5281/zenodo.7360664
HEK293	IC₅₀	>10 μM Compound: 118191391	Inhibition of the Glucose Transporter (GLUT3, SLC2A3) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A3 WT-OE cells (PubChem AID: 1794827) Inhibition of the Glucose Transporter (GLUT3, SLC2A3) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A3 WT-OE cells (PubChem AID: 1794827)	10.5281/zenodo.7360656
HEK293	IC₅₀	>10 μM Compound: 118191391	Inhibition of the Glucose Transporter (GLUT2, SLC2A2) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A2 WT-OE cells (PubChem AID: 1794829) Inhibition of the Glucose Transporter (GLUT2, SLC2A2) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A2 WT-OE cells (PubChem AID: 1794829)	10.5281/zenodo.7360664
HEK293	IC₅₀	0.24 μM Compound: 118191391	Inhibition of the Glucose Transporter (GLUT1, SLC2A1) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A1 WT-OE cells Inhibition of the Glucose Transporter (GLUT1, SLC2A1) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A1 WT-OE cells	10.5281/zenodo.7360676
HEK293	IC₅₀	0.24 μM Compound: 118191391	Inhibition of the Glucose Transporter (GLUT1, SLC2A1) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A1 WT-OE cells (PubChem AID: 1794830 Inhibition of the Glucose Transporter (GLUT1, SLC2A1) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A1 WT-OE cells (PubChem AID: 1794830	10.5281/zenodo.7360676
HEK293	IC₅₀	5.5 μM Compound: 118191391	Inhibition of the Glucose Transporter (GLUT4, SLC2A4) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A4 WT-OE cells Inhibition of the Glucose Transporter (GLUT4, SLC2A4) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A4 WT-OE cells	10.5281/zenodo.7360638
HEK293	IC₅₀	5.5 μM Compound: 118191391	Inhibition of the Glucose Transporter (GLUT4, SLC2A4) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A4 WT-OE cells (PubChem AID: 1794828) Inhibition of the Glucose Transporter (GLUT4, SLC2A4) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A4 WT-OE cells (PubChem AID: 1794828)	10.5281/zenodo.7360638
HEY	IC₅₀	1002 nM Compound: Chemical probe: BAY-876	Antiproliferative activity against human HEY cells assessed as reduction in cell viability after 72 hrs MTT assay Antiproliferative activity against human HEY cells assessed as reduction in cell viability after 72 hrs MTT assay	[PMID: 30602670]
OVCAR-3	IC₅₀	60 nM Compound: Chemical probe: BAY-876	Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against human OVCAR-3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30602670]
SK-OV-3	IC₅₀	188 nM Compound: Chemical probe: BAY-876	Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell viability after 72 hrs MTT assay Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell viability after 72 hrs MTT assay	[PMID: 30602670]

体外実験

BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	SKOV-3 and OVCAR-3 cells
Concentration:	25, 50, 75 nM
Incubation Time:	24 and 72 hours
Result:	Led to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells.

体内実験

BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female NOD-scid IL2rg^null (NSG) mice carrying SKOV-3 subcutaneous (s.c.) xenografts^[2]
Dosage:	1.5, 3, 4.5 mg/kg
Administration:	Oral administration; daily; for 28 days
Result:	Caused a clear dose-dependent inhibition of tumorigenicity.

分子量

496.42

分子式

C₂₄H₁₆F₄N₆O₂

CAS 番号

1799753-84-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C#N)C=C4)N=C3C(F)(F)F)=O)=C1)N

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (201.44 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0144 mL	10.0721 mL	20.1442 mL
5 mM	0.4029 mL	2.0144 mL	4.0288 mL
10 mM	0.2014 mL	1.0072 mL	2.0144 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.04 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.67%

Select Batch:

データシート (282 KB) SDS (393 KB)

COA (259 KB) LCMS (94 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Siebeneicher H et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Aug 23. [Content Brief]

[2]. Ma Y, et al. Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers (Basel). 2018 Dec 31;11(1). [Content Brief]

[3]. Zhang R, et al. Reductive cell death: the other side of the coin[J]. Cancer Gene Therapy, 2023, 30(7): 929-931. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0144 mL	10.0721 mL	20.1442 mL	50.3606 mL
	5 mM	0.4029 mL	2.0144 mL	4.0288 mL	10.0721 mL
	10 mM	0.2014 mL	1.0072 mL	2.0144 mL	5.0361 mL
	15 mM	0.1343 mL	0.6715 mL	1.3429 mL	3.3574 mL
	20 mM	0.1007 mL	0.5036 mL	1.0072 mL	2.5180 mL
	25 mM	0.0806 mL	0.4029 mL	0.8058 mL	2.0144 mL
	30 mM	0.0671 mL	0.3357 mL	0.6715 mL	1.6787 mL
	40 mM	0.0504 mL	0.2518 mL	0.5036 mL	1.2590 mL
	50 mM	0.0403 mL	0.2014 mL	0.4029 mL	1.0072 mL
	60 mM	0.0336 mL	0.1679 mL	0.3357 mL	0.8393 mL
	80 mM	0.0252 mL	0.1259 mL	0.2518 mL	0.6295 mL
	100 mM	0.0201 mL	0.1007 mL	0.2014 mL	0.5036 mL

BAY-876 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-8761799753-84-6BAY876BAY 876GLUTDisulfidptosisGlucose transporter orallyglucosetransporter1glycolyticmetabolismovariancancerInhibitorinhibitorinhibit

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BAY-876

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純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

BAY-876 Related Classifications

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Dilution Calculator

The molarity calculator equation

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BAY-876

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Other Forms of BAY-876:

BAY-876 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

GLUT アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

BAY-876 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

BAY-876 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

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