Galidesivir (Synonyms: BCX4430; Immucillin-A)

Name: Galidesivir
Brand: MedChemExpress
SKU: HY-18649A
Rating: 5.0 (12 reviews)

Cat. No.: HY-18649A Pureté: 98.89%: Fiche technique
COA

SDS
Instruction de manipulation
FAQs
Technical Support

Galidesivir (BCX4430), an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir inhibits some negative-sense RNA viruses with EC₅₀s ranging from ~3 to ~68 μM.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Galidesivir Chemical Structure

CAS No. : 249503-25-1

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtenir un devis
100 mg	Obtenir un devis

or Bulk Inquiry

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Avis client

Based on 12 publication(s) in Google Scholar

Other Forms of Galidesivir:

Galidesivir hydrochloride In-stock
Galidesivir dihydrochloride Obtenir un devis

12 Publications Citing Use of MCE Galidesivir

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis:

Voir toutes les isoformes

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

Voir tous les produits spécifiques à Isoform Filovirus:

Voir toutes les isoformes

EBOV MARV ZEBOV

Activité biologique
Pureté et documentation
Références
Avis client

Description

IC₅₀ & Target

RNA Polymerase

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	CC₅₀	82.8 3 Compound: Galidesivir	Cytotoxicity against human Caco-2 cells assessed as cell growth inhibition by neutral red cytopathic assay Cytotoxicity against human Caco-2 cells assessed as cell growth inhibition by neutral red cytopathic assay	[PMID: 36965227]
Huh-7	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Caco-2	CC₅₀	82.8 3 Compound: Galidesivir	Cytotoxicity against human Caco-2 cells assessed as cell growth inhibition by neutral red cytopathic assay Cytotoxicity against human Caco-2 cells assessed as cell growth inhibition by neutral red cytopathic assay	[PMID: 36965227]
Calu-3	CC₅₀	>50 3 Compound: Galidesivir	Cytotoxicity against human Calu-3 cells assessed as cell growth inhibition by neutral red cytopathic assay Cytotoxicity against human Calu-3 cells assessed as cell growth inhibition by neutral red cytopathic assay	[PMID: 36965227]
Huh-7	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Calu-3	CC₅₀	> 50 3 Compound: Galidesivir	Cytotoxicity against human Calu-3 cells assessed as cell growth inhibition by neutral red cytopathic assay Cytotoxicity against human Calu-3 cells assessed as cell growth inhibition by neutral red cytopathic assay	[PMID: 36965227]
Huh-7	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by visual analysis Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Huh-7	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Huh-7	CC₅₀	>89 3 Compound: 8; BCX4430	Cytotoxicity against human HuH7 cells Cytotoxicity against human HuH7 cells	[PMID: 31549836]
Huh-7	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by visual analysis Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Huh-7	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by visual assay Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by visual assay	[PMID: 37077387]
Huh-7	CC₅₀	>100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against human Huh-7 cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
MDCK	CC₅₀	>100 3 Compound: Galidesivir	Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
MDCK	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Huh-7	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Huh-7	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by visual assay Cytotoxicity against human Huh-7 cells infected with Yellow fever virus assessed as reduction in cell viability by visual assay	[PMID: 37077387]
MDCK	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by visual analysis Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
RD	CC₅₀	>89 3 Compound: 8; BCX4430	Cytotoxicity against human RD cells Cytotoxicity against human RD cells	[PMID: 31549836]
RD	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
RD	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Huh-7	CC₅₀	> 89 3 Compound: 8; BCX4430	Cytotoxicity against human HuH7 cells Cytotoxicity against human HuH7 cells	[PMID: 31549836]
RD	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
MDCK	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Vero	CC₅₀	>89 3 Compound: 8; BCX4430	Cytotoxicity against African green monkey Vero cells Cytotoxicity against African green monkey Vero cells	[PMID: 31549836]
Vero	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Vero	CC₅₀	>100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
MDCK	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by visual analysis Cytotoxicity against dog MDCK cells infected with Influenza A virus H1N1 assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Malaysian P 6-740 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Malaysian P 6-740 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by visual assay Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by visual assay	[PMID: 37077387]
RD	CC₅₀	> 89 3 Compound: 8; BCX4430	Cytotoxicity against human RD cells Cytotoxicity against human RD cells	[PMID: 31549836]
Vero	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero 76	CC₅₀	>295.7 3 Compound: Galidesivir	Cytotoxicity against african green monkey Vero 76 cells assessed as cell growth inhibition by neutral red cytopathic assay Cytotoxicity against african green monkey Vero 76 cells assessed as cell growth inhibition by neutral red cytopathic assay	[PMID: 36965227]
RD	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Malaysian P 6-740 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Malaysian P 6-740 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
RD	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in human RD cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero 76	CC₅₀	>100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by neutral red dye based analysis Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by neutral red dye based analysis	[PMID: 37077387]
Vero	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Vero	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by visual assay Cytotoxicity against African green monkey Vero cells infected with DENV-2 assessed as reduction in cell viability by visual assay	[PMID: 37077387]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by neutral red dye based analysis Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by neutral red dye based analysis	[PMID: 37077387]
Vero	CC₅₀	> 89 3 Compound: 8; BCX4430	Cytotoxicity against African green monkey Vero cells Cytotoxicity against African green monkey Vero cells	[PMID: 31549836]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by neutral red dye based analysis Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by neutral red dye based analysis	[PMID: 37077387]
Vero	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Malaysian P 6-740 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Malaysian P 6-740 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus PRVABC-59 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero	EC₅₀	3.8 6 Compound: 8; BCX4430	Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method Inhibition of RNA-dependent RNA polymerase in Zika virus Ugandan MR-766 infected in African green monkey Vero cells assessed as antiviral activity by neutral dye based colorimetric method	[PMID: 31549836]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by neutral red dye based analysis Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by neutral red dye based analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with MERS-CoV assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by neutral red dye based analysis Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by neutral red dye based analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with Rift valley fever virus assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by neutral red dye based assay Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by neutral red dye based assay	[PMID: 37077387]
Vero 76	CC₅₀	> 100 3 Compound: Galidesivir	Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by visual analysis Cytotoxicity against African green monkey Vero 76 cells infected with Zika virus assessed as reduction in cell viability by visual analysis	[PMID: 37077387]
Vero 76	CC₅₀	> 295.7 3 Compound: Galidesivir	Cytotoxicity against african green monkey Vero 76 cells assessed as cell growth inhibition by neutral red cytopathic assay Cytotoxicity against african green monkey Vero 76 cells assessed as cell growth inhibition by neutral red cytopathic assay	[PMID: 36965227]

In Vitro

Cellular kinases phosphorylate Galidesivir (BCX4430) to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination^[1].
Galidesivir effectively inhibits the infection of Vero cells with YFV. The EC50 determined by the neutral red uptake assay is 8.3 μg/ml (24.5 μM)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Galidesivir (BCX4430) is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, Galidesivir has demonstrated pronounced efficacy^[1].
Galidesivir (4 mg/kg; i.p.; twice daily for 7 days) is effectively in a hamster model of yellow fever (YF)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Syrian golden hamsters (hamsters infected with YF virus)^[4]
Dosage:	4 mg/kg of body weight
Administration:	I.p.; twice daily for 7 days
Result:	Significantly improved the survival of hamsters infected with YFV.

Masse moléculaire

265.27

Formule

C₁₁H₁₅N₅O₃

CAS No.

249503-25-1

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](C2=CNC3=C2N=CN=C3N)N[C@H](CO)[C@H]1O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvant et solubilité

In Vitro:

H₂O : 100 mg/mL (376.97 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7697 mL	18.8487 mL	37.6974 mL
5 mM	0.7539 mL	3.7697 mL	7.5395 mL
10 mM	0.3770 mL	1.8849 mL	3.7697 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99.29%

Select Batch:

Fiche technique (279 KB) SDS (393 KB)

COA (253 KB) HNMR (184 KB) LCMS (241 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Taylor R, et al. BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease. J Infect Public Health. 2016;9(3):220-226. [Content Brief]

[2]. Elfiky AA, et al. ICN-1229, Remdesivir, PSI-7977, Galidesivir, and GS 1278 against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Life Sci. 2020 Mar 25:117592. [Content Brief]

[3]. Warren TK, et al. Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature. 2014;508(7496):402-405. [Content Brief]

[4]. Julander JG, et al. BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model. Antimicrob Agents Chemother. 2014;58(11):6607-6614. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.7697 mL	18.8487 mL	37.6974 mL	94.2436 mL
	5 mM	0.7539 mL	3.7697 mL	7.5395 mL	18.8487 mL
	10 mM	0.3770 mL	1.8849 mL	3.7697 mL	9.4244 mL
	15 mM	0.2513 mL	1.2566 mL	2.5132 mL	6.2829 mL
	20 mM	0.1885 mL	0.9424 mL	1.8849 mL	4.7122 mL
	25 mM	0.1508 mL	0.7539 mL	1.5079 mL	3.7697 mL
	30 mM	0.1257 mL	0.6283 mL	1.2566 mL	3.1415 mL
	40 mM	0.0942 mL	0.4712 mL	0.9424 mL	2.3561 mL
	50 mM	0.0754 mL	0.3770 mL	0.7539 mL	1.8849 mL
	60 mM	0.0628 mL	0.3141 mL	0.6283 mL	1.5707 mL
	80 mM	0.0471 mL	0.2356 mL	0.4712 mL	1.1780 mL
	100 mM	0.0377 mL	0.1885 mL	0.3770 mL	0.9424 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Galidesivir Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Please select a local distributor ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Nom du produit			Requested Quantity *
Nom du demandeur *			Civilité
Adresse e-mail *			Numéro de téléphone *
Department			Nom de l'organisation *
City			État
Country or Region *
Remarques

Nom du produit			Lot #
Nom du demandeur *			Adresse e-mail *
Numéro de téléphone			Department *
Nom de l'organisation *			Country or Region *
Remarques

Galidesivir (Synonyms: BCX4430; Immucillin-A)

Avis client

Other Forms of Galidesivir:

12 Publications Citing Use of MCE Galidesivir

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis:

Voir tous les produits spécifiques à Isoform Filovirus:

Activité biologique

Pureté et documentation

Références

Avis client

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Galidesivir Related Classifications

Keywords:

Vos produits récemment consultés:

Nom
Email *

	Sorry, but the email address you supplied was invalid.

Galidesivir (Synonyms: BCX4430; Immucillin-A)

Avis client

Other Forms of Galidesivir:

Galidesivir Related Antibodies

12 Publications Citing Use of MCE Galidesivir

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis:

Voir tous les produits spécifiques à Isoform Filovirus:

Activité biologique

Pureté et documentation

Références

Avis client

Galidesivir Related Antibodies

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Galidesivir Related Classifications

Keywords:

Vos produits récemment consultés:

Avis client

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report