2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Bilirubin

ビリルビン  (Synonyms: Bilirubin)

製品番号: HY-N0323 純度: 98.0%
COA 取扱説明書 Technical Support

Bilirubin is a yellow breakdown product of heme catabolism. Bilirubin exhibits antioxidant and antimutagenic effects.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 635-65-4

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
50 mg $50 在庫あり
100 mg $80 在庫あり
250 mg $160 在庫あり
500 mg $260 在庫あり
1 g $420 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 6 publication(s) in Google Scholar

ビリルビン 関連抗体

Top Publications Citing Use of Products

    Bilirubin purchased from MedChemExpress. Usage Cited in: PLoS Negl Trop Dis. 2025 Dec 11;19(12):e0013815.  [Abstract]

    HFF cells were incubated with vehicle and bilirubin (10 μM or 40 μM) 2 h before infection with Tg RH (MOI = 0.2). The relative intracellular parasite numbers were quantified by qPCR at 72 h post-infection.

    Bilirubin purchased from MedChemExpress. Usage Cited in: Hepatology. 2024 Aug 1;80(2):403-417.  [Abstract]

    Verification of the function of bilirubin as an AhR ligand using HepG2-Lucia AhR reporter cells.

    Bilirubin purchased from MedChemExpress. Usage Cited in: J Bone Oncol. 2023 Feb 23:39:100472.

    Bilirubin (IBIL; 15 μM) markedly decreases the expression of MMP-2 and upregulates the expression of TIMP-2 in 143B and MG63 cells.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Bilirubin is a yellow breakdown product of heme catabolism[1]. Bilirubin exhibits antioxidant and antimutagenic effects[2].

    IC50 & Target

    Human Endogenous Metabolite

     

    体外実験

    Unconjugated Bilirubin inhibits the cleavage of F485-rVWF73-H, D633-rVWF73-H, and GST-rVWF71-11K by ADAMTS13 in a concentration-dependent manner with a half-maximal inhibitory concentration (IC50) of ~13 μM, ~70 μM, and ~17 μM, respectively. Unconjugated Bilirubin also dose-dependently inhibits the cleavage of multimeric VWF by ADAMTS13 under denaturing conditions[1]. Bilirubin exhibits antioxidant and antimutagenic effects in vitro[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ビリルビン 関連抗体
    臨床実験
    分子量

    584.66

    分子式

    C33H36N4O6
    CAS 番号
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    CC(C(N/1)=O)=C(C=C)C1=C\C2=C(C)C(CCC(O)=O)=C(CC3=C(CCC(O)=O)C(C)=C(/C=C4NC(C(C=C)=C\4C)=O)N3)N2
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    0.1 M NaOH : 9.09 mg/mL (15.55 mM; ultrasonic and warming and adjust pH to 11 with 0.1 N NaOH and heat to 60°C)

    DMSO : 5.38 mg/mL (9.20 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    0.1 M HCl : < 1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7104 mL 8.5520 mL 17.1040 mL
    5 mM 0.3421 mL 1.7104 mL 3.4208 mL
    10 mM 0.1710 mL 0.8552 mL 1.7104 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 10 mg/mL (17.10 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    純度とドキュメンテーション

    純度: 98.71%

    COA (257 KB) HNMR (322 KB) LCMS (94 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / 0.1 M NaOH 1 mM 1.7104 mL 8.5520 mL 17.1040 mL 42.7599 mL
    5 mM 0.3421 mL 1.7104 mL 3.4208 mL 8.5520 mL
    0.1 M NaOH 10 mM 0.1710 mL 0.8552 mL 1.7104 mL 4.2760 mL
    15 mM 0.1140 mL 0.5701 mL 1.1403 mL 2.8507 mL
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    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Bilirubin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Bilirubin635-65-4Endogenous MetabolitehemecatabolismantioxidantantimutagenicInhibitorinhibitorinhibit

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    製品名:
    Bilirubin
    製品番号:
    HY-N0323
    数量:
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