2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. CNQX

CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist. CNQX blocks the expression of fear-potentiated startle in rats.

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CAS. Nr. : 115066-14-3

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Based on 16 publication(s) in Google Scholar

Other Forms of CNQX:

CNQX Related Antibodies

Top Publications Citing Use of Products

    CNQX purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011.  [Abstract]

    Sample traces of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.

    CNQX purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011.  [Abstract]

    Sample amplitude curve of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.

    CNQX purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2025 Jan 27;23(1):e3003011.  [Abstract]

    Averaged amplitude of eEPSCs in the RSC-ACC projections with the perfusion of D-AP5 (50 μM), GYKI53655 (100 μM), and CNQX (20 μM) sequentially under the presence of picrotoxin (50 μM) (one-way RM ANOVA with Sidak multiple comparisons tests.

    CNQX purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 May 15;15(1):4122.  [Abstract]

    Light-evoked EPSCs in vCE L5a PCs were abolished after bath application of tetrodotoxin (TTX) but were then reintroduced following application of 4-Aminopyridine, indicating the monosynaptic nature of connections from V2 to vCE L5a. These restored responses were blocked by AMPA receptor antagonist CNQX.

    CNQX purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 May 15;15(1):4122.  [Abstract]

    The light-evoked EPSCs were abolished by TTX and rescued by 4-AP, but severely attenuated by CNQX.

    Alle iGluR Isoform-spezifische Produkte anzeigen:

    Alle Isoformen anzeigen
    AMPA Receptor NMDA Receptor Kainate Receptor

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    Beschreibung

    CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5].

    IC50 & Target

    Kainate Receptor

     

    In Vitro

    CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
    CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    CNQX Related Antibodies
    In Vivo

    CNQX (FG9065; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices[2].
    CNQX (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats weighing 180-200 g[4]
    Dosage: 0.75, 1.5, and 3 mg/kg
    Administration: IP; 20 min before testing
    Result: Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval
    Molekulargewicht

    232.15

    Formel

    C9H4N4O4
    CAS. Nr.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    O=C1C(NC2=CC([N+]([O-])=O)=C(C#N)C=C2N1)=O
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Lösungsmittel & Löslichkeit
    In Vitro: 

    DMSO : 20 mg/mL (86.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3076 mL 21.5378 mL 43.0756 mL
    5 mM 0.8615 mL 4.3076 mL 8.6151 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molaritätsrechner

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    Working solution concentration: mg/mL
    Reinheit & Dokumentation

    Purity: 99.65%

    SDS (459 KB)

    COA (253 KB) HNMR (186 KB) LCMS (83 KB)

    Handling Instructions (2659 KB)
    Verweise

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.3076 mL 21.5378 mL 43.0756 mL 107.6890 mL
    5 mM 0.8615 mL 4.3076 mL 8.6151 mL 21.5378 mL
    10 mM 0.4308 mL 2.1538 mL 4.3076 mL 10.7689 mL
    15 mM 0.2872 mL 1.4359 mL 2.8717 mL 7.1793 mL
    20 mM 0.2154 mL 1.0769 mL 2.1538 mL 5.3844 mL
    25 mM 0.1723 mL 0.8615 mL 1.7230 mL 4.3076 mL
    30 mM 0.1436 mL 0.7179 mL 1.4359 mL 3.5896 mL
    40 mM 0.1077 mL 0.5384 mL 1.0769 mL 2.6922 mL
    50 mM 0.0862 mL 0.4308 mL 0.8615 mL 2.1538 mL
    60 mM 0.0718 mL 0.3590 mL 0.7179 mL 1.7948 mL
    80 mM 0.0538 mL 0.2692 mL 0.5384 mL 1.3461 mL
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    CNQX Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CNQX115066-14-3FG9065FG 9065FG-9065iGluRIonotropic glutamate receptorsAMPAkainatenon-NMDAfear-potentiatedstartleInhibitorinhibitorinhibit

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