1. Anti-infection
  2. Fungal
  3. Carbendazim

Carbendazim 

Cat. No.: HY-13582 Purity: 99.81%
Handling Instructions

Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as SeproriaFusarium and Sclerotina. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.

For research use only. We do not sell to patients.

Carbendazim Chemical Structure

Carbendazim Chemical Structure

CAS No. : 10605-21-7

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 84 In-stock
Estimated Time of Arrival: December 31
1 g USD 108 In-stock
Estimated Time of Arrival: December 31
5 g USD 324 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Carbendazim is a potent and orally active broad-spectrum benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as SeproriaFusarium and Sclerotina[1][3]. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma[3].

In Vitro

Carbendazim (4-60 µM; 24 hours) has no effects on viability of HeLa cells in a CCK-8 assay[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Carbendazim (oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days) induces hepatic lipid metabolism disorder, it results in a significant increase of hepatic lipid accumulation and triglyceride (TG) levels in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old male ICR mice[2]
Dosage: 100 and 500 mg/kg
Administration: Oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days
Result: Increased the relative mRNA levels of some key genes related to lipogenesis and TG synthesis.
Up-regulated mRNA levels of IL-1b and IL-6 in the liver in mice.
Increased the serum concentrations of 2 proinflammatory cytokines IL-1b and IL-6 at 500 mg/kg. However, in the fat tissues, onlyIL-1b in the CBZ-500-treated group increased significantly as compared with the control group.
Clinical Trial
Molecular Weight

191.19

Formula

C₉H₉N₃O₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.8 mg/mL (35.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2304 mL 26.1520 mL 52.3040 mL
5 mM 1.0461 mL 5.2304 mL 10.4608 mL
10 mM 0.5230 mL 2.6152 mL 5.2304 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (2.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (2.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Carbendazim
Cat. No.:
HY-13582
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