Deschloroclozapine

Name: Deschloroclozapine
Brand: MedChemExpress
SKU: HY-42110
Rating: 5.0 (83 reviews)

製品番号: HY-42110 純度: 99.93%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist, with blood-brain barrier permeability. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K_i of 6.3 and 4.2 nM, respectively. [¹¹C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 1977-07-7

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 70	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 70	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$64	在庫あり	Estimated Time of Arrival: December 31
10 mg	$100	在庫あり	Estimated Time of Arrival: December 31
25 mg	$210	在庫あり	Estimated Time of Arrival: December 31
50 mg	$350	在庫あり	Estimated Time of Arrival: December 31
100 mg	$550	在庫あり	Estimated Time of Arrival: December 31
1 g	$1900	在庫あり	Estimated Time of Arrival: December 31
5 g		お問い合わせ
10 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 83 publication(s) in Google Scholar

Other Forms of Deschloroclozapine:

Deschloroclozapine dihydrochloride 在庫あり

顧客検証

In Vivo Efficacy Study

: Deschloroclozapine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]; Deschloroclozapine dihydrochloride (DCZ; 0.1 mg/kg; ip) showed mCh + DCZ‐, Gi + saline‐ and Gi + DCZ‐treated mice displayed normal sociability.

: Deschloroclozapine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2406192. [Abstract]; Deschloroclozapine dihydrochloride (DCZ; 0.1 mg/kg; ip) showed mCh + DCZ‐ and Gi + saline ‐treated mice displayed a marked preference for novel conspecifics, Gi + DCZ‐treated mice did not differentiate between familiar and novel mice.

: Deschloroclozapine purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 May 14:8:0701. [Abstract]; Representative immunofluorescent images of c-Fos (Green) in mCherry-positive MPOA GABAergic neurons (red) after saline or Deschloroclozapine (DCZ) (100 μg/kg; i.p.) treatment in GAD2-IRES-Cre mice.

: Deschloroclozapine purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 2:2025.04.18.649578.; Deschloroclozapine dihydrochloride (DCZ; 0.02 mg/kg; ip) caused an increase in SST interneuron responses in mice.

: Deschloroclozapine purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 2:2025.04.18.649578.; Deschloroclozapine dihydrochloride (DCZ; 0.02 mg/kg; ip) reduced activity in VIP interneurons and prevented S1 potentiation upon RWS stimulation alone. In the presence of DCZ, RWS stimulation suppresses L2/3 pyramidal cell potentiation, and even causes depression, even when the CF is not co-activated.

mAChR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

mAChR3

mAChR4

体外実験

Designer Receptors Exclusively Activated by Designer Drugs (DREADD) are a chemogenetic approach for remote manipulation of neuronal activity in freely-moving animals. DREADDs comprise mutated G protein-coupled receptors (GPCRs) that do not respond to their endogenous neurotransmitter, but do respond to an otherwise “inert” exogenous substance^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Deschloroclozapine (0.3 mg/kg; intramuscularly) impairs working memory function in male rhesus macaques (aged between 5 and 6 years and weighing 5.5-7.9 kg)^[3].
Deschloroclozapine (0.1 mg/kg; i.m) is effective at activating DREADD receptors in vivo and reversibly inducing behavioral effects in monkeys^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

292.39

分子式

C₁₈H₂₀N₄

CAS 番号

1977-07-7

Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1CCN(C2=NC3=CC=CC=C3NC4=CC=CC=C42)CC1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (342.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4201 mL	17.1004 mL	34.2009 mL
5 mM	0.6840 mL	3.4201 mL	6.8402 mL
10 mM	0.3420 mL	1.7100 mL	3.4201 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
Protocol 3

Add each solvent one by one: 5% DMSO 40% PEG300 5% Tween-80 50% Saline
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution
Protocol 4

Add each solvent one by one: 5% DMSO 95% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution
Protocol 5

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.11 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.93%

Select Batch:

データシート (281 KB) SDS (394 KB)

COA (257 KB) HNMR (252 KB) RP-HPLC (264 KB) MS (68 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475. [Content Brief]

[2]. Hu F, et al. ¹⁸F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047. [Content Brief]

[3]. Upright NA, et al. Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. Neuropsychopharmacology. 2020;45(11):1793-1798. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4201 mL	17.1004 mL	34.2009 mL	85.5022 mL
	5 mM	0.6840 mL	3.4201 mL	6.8402 mL	17.1004 mL
	10 mM	0.3420 mL	1.7100 mL	3.4201 mL	8.5502 mL
	15 mM	0.2280 mL	1.1400 mL	2.2801 mL	5.7001 mL
	20 mM	0.1710 mL	0.8550 mL	1.7100 mL	4.2751 mL
	25 mM	0.1368 mL	0.6840 mL	1.3680 mL	3.4201 mL
	30 mM	0.1140 mL	0.5700 mL	1.1400 mL	2.8501 mL
	40 mM	0.0855 mL	0.4275 mL	0.8550 mL	2.1376 mL
	50 mM	0.0684 mL	0.3420 mL	0.6840 mL	1.7100 mL
	60 mM	0.0570 mL	0.2850 mL	0.5700 mL	1.4250 mL
	80 mM	0.0428 mL	0.2138 mL	0.4275 mL	1.0688 mL
	100 mM	0.0342 mL	0.1710 mL	0.3420 mL	0.8550 mL