2. Neuronal Signaling
  3. Serotonin Transporter
  4. Escitalopram oxalate

Escitalopram (oxalate)  (Synonyms: (S)-Citalopram (oxalate); (S)-(+)-Citalopram (oxalate))

製品番号: HY-14258A 純度: 99.97%
COA 取扱説明書 Technical Support

Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression.

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Escitalopram oxalate

Escitalopram (oxalate) 構造式

CAS 番号 : 219861-08-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 46 在庫あり
Solution
10 mM * 1 mL in DMSO USD 46 在庫あり
Solid
5 mg $42 在庫あり
10 mg $66 在庫あり
50 mg $92 在庫あり
100 mg $106 在庫あり
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500 mg   お問い合わせ  

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Based on 11 publication(s) in Google Scholar

Other Forms of Escitalopram oxalate:

Escitalopram (oxalate) 関連抗体

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製品説明

Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a Ki of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression[1][2].

IC50 & Target

Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)[1]
体内実験

Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats[3].
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively [4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[3]
Dosage: 10 mg/kg
Administration: I.p.; daily for 28 days
Result: Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats.
Animal Model: APP-PS1 hemizygous female mice (4 months of age)[4]
Dosage: 2.5-5 mg/kg
Administration: Daily; drinking water for a total of 4 months
Result: At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.
分子量

414.43

分子式

C22H23FN2O5
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C([C@@]2(CCCN(C)C)C(C=CC(C#N)=C3)=C3CO2)C=C1.O=C(O)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 116.67 mg/mL (281.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 14.29 mg/mL (34.48 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4130 mL 12.0648 mL 24.1295 mL
5 mM 0.4826 mL 2.4130 mL 4.8259 mL
10 mM 0.2413 mL 1.2065 mL 2.4130 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: ≥ 100 mg/mL (241.30 mM); Clear solution

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.4130 mL 12.0648 mL 24.1295 mL 60.3238 mL
5 mM 0.4826 mL 2.4130 mL 4.8259 mL 12.0648 mL
10 mM 0.2413 mL 1.2065 mL 2.4130 mL 6.0324 mL
15 mM 0.1609 mL 0.8043 mL 1.6086 mL 4.0216 mL
20 mM 0.1206 mL 0.6032 mL 1.2065 mL 3.0162 mL
25 mM 0.0965 mL 0.4826 mL 0.9652 mL 2.4130 mL
30 mM 0.0804 mL 0.4022 mL 0.8043 mL 2.0108 mL
DMSO 40 mM 0.0603 mL 0.3016 mL 0.6032 mL 1.5081 mL
50 mM 0.0483 mL 0.2413 mL 0.4826 mL 1.2065 mL
60 mM 0.0402 mL 0.2011 mL 0.4022 mL 1.0054 mL
80 mM 0.0302 mL 0.1508 mL 0.3016 mL 0.7540 mL
100 mM 0.0241 mL 0.1206 mL 0.2413 mL 0.6032 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Escitalopram oxalate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Escitalopram219861-08-2(S)-Citalopram(S)-(+)-CitalopramSerotonin Transporter5-HTTSERTSLC6A4S-enantiomerreuptakeselectivityantidepressantdepressioncognitiveimpairmentsInhibitorinhibitorinhibit

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