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Ipatasertib dihydrochloride

(Synonyms: GDC-0068 dihydrochloride; RG-7440 dihydrochloride)
66 Cited Publications
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Based on 66 publication(s) in Google Scholar

Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.19%
  • CAS No.: 1396257-94-5
  • Formula: C24H34Cl3N5O2
  • Molecular Weight:530.92
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Ipatasertib dihydrochloride Chemical Structure
    Ipatasertib dihydrochloride Chemical Structure
  • Experimental Validation Results for Ipatasertib dihydrochloride
  • Experimental Validation Results for Ipatasertib dihydrochloride
  • Experimental Validation Results for Ipatasertib dihydrochloride
  • Experimental Validation Results for Ipatasertib dihydrochloride
CAS No.: 1396257-94-5
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WBCell Proliferation/Viability Assay
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  • Ipatasertib dihydrochloride Chemical Structure
    Ipatasertib dihydrochloride Chemical Structure
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    Ipatasertib dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 25;16(1):1774. [Abstract]

    Customer Validation
     Viable cell numbers and PUFA-PC ratio after treatment with LY294002 (iPI3K, 10 µM), picropodophyllin (iRTK, 10 µM), ipatasertib (iAkt, 10 µM), or fatostatin (iSREBP1, 20 µM) for 48 h.

  • 1/16

    Ipatasertib dihydrochloride purchased from MedChemExpress. Usage Cited in: Skelet Muscle. 2021 Mar 15;11(1):6. [Abstract]

    Customer Validation
     The western blot analysis and quantification of phosphorylated and all forms of AKT and P70, MyoG, and MyoD, after transfecting miR-1290/miR-NC with or without GDC0068. GDC-0068 inhibits miR-1290-activated phosphorylation of AKT and P70 in C2C12 myoblasts.

  • 1/16

    Ipatasertib dihydrochloride purchased from MedChemExpress. Usage Cited in: Front Oncol. 2021 Nov 24:11:766298. [Abstract]

    Customer Validation
     Ipatasertib (0.625, 1.25, 5 µM; 24 h) increases the phosphorylation of AKT in MFM-223 FGFR2amp cells.

  • 1/16

    Ipatasertib dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2020 Oct:180:114145. [Abstract]

    Customer Validation
     C2C12 myoblasts were pre-incubated with 2.5 μM GDC-0068 for 30 min then treated with 0.2 μM S-Rg3. After incubation with S-Rg3 for 72 h and 24 h, Western blotting is used to detect levels of Myf5 and myogenin in C2C12 myoblasts after incubation of cells with S-Rg3 for 120 h. GDC-0068 inhibits S-Rg3-activated phosphorylation of Akt and mTOR in C2C12 myoblasts.

  • Ipatasertib dihydrochloride