1. Anti-infection
  2. Bacterial

Gatifloxacin mesylate (Synonyms: AM 1155 mesylate; BMS 206584-01 mesylate; PD 135432 mesylate)

Cat. No.: HY-10581B
Handling Instructions

Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

For research use only. We do not sell to patients.

Gatifloxacin mesylate Chemical Structure

Gatifloxacin mesylate Chemical Structure

CAS No. : 316819-28-0

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  • References

Description

Gatifloxacin (mesylate) is an antibiotic of the fourth-generation fluoroquinolone family, it inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Target: Antibacterial Gatifloxacin (mesylate) is the mesylate salt of Gatifloxacin which is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. Gatifloxacin had activity equal to that of tosufloxacin and activity more potent than those of norfloxacin, ofloxacin, ciprofloxacin, and sparfloxacin against the second-step mutants (grlA gyrA; gatifloxacin MIC range, 1.56 to 3.13 microg/ml) and had the most potent activity against the third-step mutants (grlA gyrA grlA; gatifloxacin MIC range, 1.56 to 6.25 microg/ml), suggesting that gatifloxacin possesses the most potent inhibitory activity against singly mutated topo IV and singly mutated DNA gyrase among the quinolones tested [1]. Ophthalmic gatifloxacin 0.3% is at least as effective as ciprofloxacin at healing corneal ulcers infected with Pseudomonas aeruginosa when gatifloxacin is administered less frequently than ciprofloxacin. Trends favored gatifloxacin in fluorescein retention scores [2]. Clinical indications: Bacterial infection Toxicity: Hepatotoxicity; Acute pancreatitis [3]; Torsades de pointes [4]

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Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1209 mL 10.6045 mL 21.2089 mL
5 mM 0.4242 mL 2.1209 mL 4.2418 mL
10 mM 0.2121 mL 1.0604 mL 2.1209 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

471.50

Formula

C₂₀H₂₆FN₃O₇S

CAS No.

316819-28-0

SMILES

CC1NCCN(C2=C(F)C=C3C(N(C4CC4)C=C(C(O)=O)C3=O)=C2OC)C1.O=S(C)(O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Gatifloxacin mesylate
Cat. No.:
HY-10581B
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Gatifloxacin mesylate

Cat. No.: HY-10581B