L-Ornithine hydrochloride

Name: L-Ornithine hydrochloride
Brand: MedChemExpress
SKU: HY-W017018
Rating: 5.0 (9 reviews)

Art. -Nr.: HY-W017018 Reinheit: 99.78%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective.

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CAS. Nr. : 3184-13-2

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	Auf Lager	Estimated Time of Arrival: December 31
Solid
100 mg	Auf Lager	Estimated Time of Arrival: December 31
500 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Auf Lager	Estimated Time of Arrival: December 31
5 g	Auf Lager	Estimated Time of Arrival: December 31
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50 g	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 9 publication(s) in Google Scholar

Other Forms of L-Ornithine hydrochloride:

L-Ornithine monohydrochloride,suitable for cell culture In-stock
L-Ornithine-d₆ hydrochloride In-stock
L-Ornithine-1,2,3,4,5-¹³C₅ hydrochloride In-stock
L-Ornithine-d₂ hydrochloride In-stock
L-Ornithine-d₇ hydrochloride In-stock
L-Ornithine-¹⁵N₂ hydrochloride In-stock
L-Ornithine In-stock
L-Ornithine hydrochloride (Standard) In-stock
L-Ornithine-1,2-¹³C₂ hydrochloride Angebot einholen

9 Publications Citing Use of MCE L-Ornithine hydrochloride

ELISA

: L-Ornithine hydrochloride purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2025 Jun;18(3):459-470. [Abstract]; After treating macrophages with siLACC1 and L-ornithine (Orn, 1 nM, 48 h), ELISA was utilized to detect proinflammatory factors in macrophages.

: L-Ornithine hydrochloride purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2025 Jun;18(3):459-470. [Abstract]; After treating macrophages with siLACC1 and L-ornithine (Orn, 1 nM, 48 h), Western blot was utilized to measure the expression of proinflammatory factors in macrophages.

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Human Endogenous Metabolite Microbial Metabolite

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective^[1]^[2].

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	237 3 Compound: 76654	Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863) Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)	10.5281/zenodo.6782708
HEK293	EC₅₀	237 3 Compound: 76654	Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863) Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)	10.5281/zenodo.6782708
HEK293	EC₅₀	237 3 Compound: 76654	Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells	10.5281/zenodo.6782708

In Vitro

L-Ornithine (0-10 mM) activates the CaSR in a concentration-dependent manner and exerts effects on Ca²⁺ signaling in HK-2 cells^[2].
L-Ornithine (10 mM) activates TRPC channels mediated Ca²⁺ entry pathway in HK-2 cells^[2].
L-Ornithine (100 or 300 μM; 24 h) shows the protection against ROS generation in HK-2 cells via ROCE pathway^[2].
L-Ornithine (10 μM) can protect the ROS and oxidative damage in HK-2 cells exposed to H₂O₂^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Klinische Studie

Molekulargewicht

168.62

Formel

C₅H₁₃ClN₂O₂

CAS. Nr.

3184-13-2

Appearance

Solid

Color

White to off-white

SMILES

NCCC[C@@](N)([H])C(O)=O.Cl

Structure Classification

Amino acids

Initial Source

Microorganisms

Endogenous metabolite

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 50 mg/mL (296.52 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9305 mL	29.6525 mL	59.3050 mL
5 mM	1.1861 mL	5.9305 mL	11.8610 mL
10 mM	0.5930 mL	2.9652 mL	5.9305 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (593.05 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.91%

Select Batch:

Data Sheet (272 KB) SDS (394 KB)

COA (245 KB) HNMR (183 KB) OR (216 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Demura S, et al. Effect of L-ornithine hydrochloride ingestion on intermittent maximal anaerobic cycle ergometer performance and fatigue recovery after exercise. Eur J Appl Physiol. 2011 Nov;111(11):2837-43. [Content Brief]

[2]. Shin S, et al. l-ornithine activates Ca2+ signaling to exert its protective function on human proximal tubular cells. Cell Signal. 2020 Mar;67:109484. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.9305 mL	29.6525 mL	59.3049 mL	148.2624 mL
	5 mM	1.1861 mL	5.9305 mL	11.8610 mL	29.6525 mL
	10 mM	0.5930 mL	2.9652 mL	5.9305 mL	14.8262 mL
	15 mM	0.3954 mL	1.9768 mL	3.9537 mL	9.8842 mL
	20 mM	0.2965 mL	1.4826 mL	2.9652 mL	7.4131 mL
	25 mM	0.2372 mL	1.1861 mL	2.3722 mL	5.9305 mL
	30 mM	0.1977 mL	0.9884 mL	1.9768 mL	4.9421 mL
	40 mM	0.1483 mL	0.7413 mL	1.4826 mL	3.7066 mL
	50 mM	0.1186 mL	0.5930 mL	1.1861 mL	2.9652 mL
	60 mM	0.0988 mL	0.4942 mL	0.9884 mL	2.4710 mL
	80 mM	0.0741 mL	0.3707 mL	0.7413 mL	1.8533 mL
	100 mM	0.0593 mL	0.2965 mL	0.5930 mL	1.4826 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.