2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Ornithine hydrochloride

L-オルニチン 塩酸塩  (Synonyms: L-Ornithine (hydrochloride))

製品番号: HY-W017018 純度: 99.78%
COA 取扱説明書 Technical Support

L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective.

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CAS 番号 : 3184-13-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
100 mg $25 在庫あり
500 mg $40 在庫あり
1 g $48 在庫あり
5 g $68 在庫あり
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カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Other Forms of L-Ornithine hydrochloride:

L-オルニチン 塩酸塩 関連抗体

Top Publications Citing Use of Products

    L-Ornithine hydrochloride purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2025 Jun;18(3):459-470.  [Abstract]

    After treating macrophages with siLACC1 and L-ornithine (Orn, 1 nM, 48 h), ELISA was utilized to detect proinflammatory factors in macrophages.

    L-Ornithine hydrochloride purchased from MedChemExpress. Usage Cited in: J Cardiovasc Transl Res. 2025 Jun;18(3):459-470.  [Abstract]

    After treating macrophages with siLACC1 and L-ornithine (Orn, 1 nM, 48 h), Western blot was utilized to measure the expression of proinflammatory factors in macrophages.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    L-Ornithine hydrochloride is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine hydrochloride shows nephroprotective[1][2].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    237 μM
    Compound: 76654
    Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells
    Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells
    		10.5281/zenodo.6782708
    HEK293 EC50
    237 μM
    Compound: 76654
    Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)
    Substrate uptake by the Cationic Amino Acid Transporter (CAT-3, SLC7A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC7A3 cells (PubChem AID: 1745863)
    		10.5281/zenodo.6782708
    体外実験

    L-Ornithine (0-10 mM) activates the CaSR in a concentration-dependent manner and exerts effects on Ca2+ signaling in HK-2 cells[2].
    L-Ornithine (10 mM) activates TRPC channels mediated Ca2+ entry pathway in HK-2 cells[2].
    L-Ornithine (100 or 300 μM; 24 h) shows the protection against ROS generation in HK-2 cells via ROCE pathway[2].
    L-Ornithine (10 μM) can protect the ROS and oxidative damage in HK-2 cells exposed to H2O2[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-オルニチン 塩酸塩 関連抗体
    臨床実験
    分子量

    168.62

    分子式

    C5H13ClN2O2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    NCCC[C@@](N)([H])C(O)=O.Cl
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
    溶剤 & 溶解度
    体外: 

    H2O : 50 mg/mL (296.52 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.9305 mL 29.6525 mL 59.3050 mL
    5 mM 1.1861 mL 5.9305 mL 11.8610 mL
    10 mM 0.5930 mL 2.9652 mL 5.9305 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

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    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (593.05 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.91%

    COA (245 KB) HNMR (183 KB) OR (216 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.9305 mL 29.6525 mL 59.3049 mL 148.2624 mL
    5 mM 1.1861 mL 5.9305 mL 11.8610 mL 29.6525 mL
    10 mM 0.5930 mL 2.9652 mL 5.9305 mL 14.8262 mL
    15 mM 0.3954 mL 1.9768 mL 3.9537 mL 9.8842 mL
    20 mM 0.2965 mL 1.4826 mL 2.9652 mL 7.4131 mL
    25 mM 0.2372 mL 1.1861 mL 2.3722 mL 5.9305 mL
    30 mM 0.1977 mL 0.9884 mL 1.9768 mL 4.9421 mL
    40 mM 0.1483 mL 0.7413 mL 1.4826 mL 3.7066 mL
    50 mM 0.1186 mL 0.5930 mL 1.1861 mL 2.9652 mL
    60 mM 0.0988 mL 0.4942 mL 0.9884 mL 2.4710 mL
    80 mM 0.0741 mL 0.3707 mL 0.7413 mL 1.8533 mL
    100 mM 0.0593 mL 0.2965 mL 0.5930 mL 1.4826 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    L-Ornithine hydrochloride Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Ornithine3184-13-2Endogenous Metaboliteurea cycleremoving excess nitrogennephroprotectiveHK-2Inhibitorinhibitorinhibit

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    製品名:
    L-Ornithine hydrochloride
    製品番号:
    HY-W017018
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