2. Immunology/Inflammation
  3. NO Synthase
  4. Kuwanon A

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.

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Kuwanon A

Kuwanon A Estructura química

No. CAS : 62949-77-3

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Based on 1 publication(s) in Google Scholar

Kuwanon A Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Kuwanon A

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Descripciòn

Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC50 of 10.5 μM.

IC50 & Target

IC50: 10.5 μM (nitric oxide)[1]
Cellular Effect
Cell Line Type Value Description References
Calu-3 CC50
47.7 3
Compound: 22
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability
[PMID: 36651644]
HEK293 IC50
5.3 3
Compound: 4
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
[PMID: 21511472]
Calu-3 CC50
47.7 3
Compound: 22
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability
[PMID: 36651644]
HEK293 IC50
5.3 3
Compound: 4
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
[PMID: 21511472]
HEK293 IC50
5.3 3
Compound: 4
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay
[PMID: 21511472]
In Vitro

Kuwanon A shows significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes with TG inhibition values of 47.1%. Kuwanon A also shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells with an IC50 of 10.5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kuwanon A Related Antibodies
Peso molecular

420.45

Fòrmula

C25H24O6
No. CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C/C=C(C)\C)=C(C2=C3C(C=CC(C)(C)O3)=C(O)C=C2)OC4=CC(O)=CC(O)=C14
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pureza y Documentación
Referencias
Ensayo celular
[1]

RAW264.7 cells are treated with Kuwanon A (3, 10, 20, 30, 100 μM). Cell viability is measured using the MTT assay[1].

MCE no ha confirmado la precisión de estos métodos independientemente. Son solo para referencia.
Referencias
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Kuwanon A Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kuwanon A62949-77-3NO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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Nombre del producto:
Kuwanon A
Cat. No.:
HY-N2300
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