1. Anti-infection
  2. Bacterial
  3. Marbofloxacin

Marbofloxacin 

Cat. No.: HY-B0126 Purity: 99.60%
Handling Instructions

Marbofloxacin is a potent antibiotic of which depends upon its inhibition of DNA-gyrase. Marbofloxacin is a synthetic, broad spectrum bactericidal agent.

For research use only. We do not sell to patients.

Marbofloxacin Chemical Structure

Marbofloxacin Chemical Structure

CAS No. : 115550-35-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 72 In-stock
Estimated Time of Arrival: December 31
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Description

Marbofloxacin is a potent antibiotic of which depends upon its inhibition of DNA-gyrase. Marbofloxacin is a synthetic, broad spectrum bactericidal agent. Target: DNA-gyrase Marbofloxacin is a third-generation fluoroquinolone for veterinary use, the antimicrobial of which depends upon its inhibition of DNA-gyrase and topoisomerase IV. With a broad spectrum bactericidal activity and good efficacy, marbofloxacin is indicated for dermatological, respiratory and urinary tract infections due to both Gram-positive and Gram-negative bacteria and Mycoplasma [1]. Administration of Marbofloxacin at 6 mg/kg once daily for 7 days in a Staphylococcus aureus infection in tissue cages in ponies is not effective for the elimination of S. aureus infections from secluded sites [2]. The pharmacokinetic properties of marbofloxacin were investigated in 6 horses after i.v., subcutaneous and oral administration of a single dose of 2 mg/kg bwt and the minimal inhibitory concentrations (MIC) assessed for bacteria isolated from equine infectious pathologies. The clearance of marbofloxacin was mean +/- s.d. 0.25 +/- 0.05 l/kg/h and the terminal half-life 756 +/- 1.99 h. The marbofloxacin absolute bioavailabilities after subcutaneous and oral administration were 98 +/- 11% and 62 +/- 8%, respectively. Considering the breakpoint values of efficacy indices for fluoroquinolones, a marbofloxacin dosage regimen of 2 mg/kg bwt/24 h by i.v., subcutaneous or oral routes was more appropriate for enterobacteriaceae than for S. aureus [3]. Toxicity: cramps; vomiting; anorexia; soft stools; diarrhoea

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 3.8 mg/mL (10.49 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7597 mL 13.7984 mL 27.5969 mL
5 mM 0.5519 mL 2.7597 mL 5.5194 mL
10 mM 0.2760 mL 1.3798 mL 2.7597 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

362.36

Formula

C₁₇H₁₉FN₄O₄

CAS No.

115550-35-1

SMILES

O=C(C(C1=O)=CN2N(C)COC3=C(N4CCN(C)CC4)C(F)=CC1=C32)O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Marbofloxacin
Cat. No.:
HY-B0126
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Marbofloxacin

Cat. No.: HY-B0126