2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Midodrine hydrochloride

Midodrine hydrochloride  (Synonyms: (±)-Midodrine hydrochloride)

Cat. No.: HY-12749A Pureza: 99.9%
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Midodrine hydrochloride ((±)-Midodrine hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine hydrochloride can strengthen vascular contraction. Midodrine hydrochloride can be used for the researches of cardiovascular disease, such as orthostatic hypotension.

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Midodrine hydrochloride

Midodrine hydrochloride Estructura química

No. CAS : 43218-56-0

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in Water En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

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Other Forms of Midodrine hydrochloride:

Midodrine hydrochloride Related Antibodies

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Descripciòn

Midodrine hydrochloride ((±)-Midodrine hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine hydrochloride can strengthen vascular contraction. Midodrine hydrochloride can be used for the researches of cardiovascular disease, such as orthostatic hypotension[1][2][3].

IC50 & Target

α adrenergic receptor

 

In Vitro

Midodrine hydrochloride (30 μM, 0-24 h) increases p-AMPK and PPARδ expression in C2C12, HL1 and HepG2 cells[3].
Midodrine hydrochloride (30 μM, 0-1 min) increases Ca2+ in C2C12, HL1 and HepG2 cells[3].
Midodrine hydrochloride (30 μM) increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells[3].
Midodrine hydrochloride (30-100 μM) reduces cellular lipid content in 3T3-L1 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Midodrine hydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: C2C12, HL1 and HepG2 cells
Concentration: 30 μM
Incubation Time: 0, 0.5, 1, 3, 6, and 24 h
Result: Increased p-AMPK and PPARδ expression.
In Vivo

Midodrine hydrochloride (20 mg/kg, i.p., 30 mins before Paf) reduces platelet-activating factor (Paf)-induced death in mice[1].
Midodrine hydrochloride (5 mg/kg, i.g.) shows anti-hypotensive effects in orthostatic hypotension rats models[2].
Midodrine hydrochloride (0.3 mg/kg, p.o., 4 weeks.) relieves hypertension in spontaneously hypertensive rats models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Orthostatic hypotension rats models[2]
Dosage: 5 mg/kg
Administration: Orally gavage
Result: Remarkably increased the baselines of SBP, DBP and MAP, but decreased HR.
Animal Model: Spontaneously hypertensive rats models[3]
Dosage: 0.3 mg/kg
Administration: Orally administration, 4 weeks
Result: Increased p-AMPK, PPARδ and PGC-1α expression.
Increased SDH activity and ATP levels.
Increased expression of uncoupling protein 3 (UCP3).
Decreased left ventricular mass and the harvested cardiac weight.
Reduced both systolic and diastolic BP after 1 week.
Reduced serum total cholesterol, LDL cholesterol, and HDL cholesterol.
Peso molecular

290.74

Fòrmula

C12H19ClN2O4
No. CAS
Appearance

Solid

Color

White to yellow

SMILES

O=C(NCC(C1=CC(OC)=CC=C1OC)O)CN.[H]Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : 100 mg/mL (343.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4395 mL 17.1975 mL 34.3950 mL
5 mM 0.6879 mL 3.4395 mL 6.8790 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 99.9%

SDS (420 KB)

COA (246 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.4395 mL 17.1975 mL 34.3950 mL 85.9875 mL
5 mM 0.6879 mL 3.4395 mL 6.8790 mL 17.1975 mL
10 mM 0.3439 mL 1.7197 mL 3.4395 mL 8.5987 mL
15 mM 0.2293 mL 1.1465 mL 2.2930 mL 5.7325 mL
20 mM 0.1720 mL 0.8599 mL 1.7197 mL 4.2994 mL
25 mM 0.1376 mL 0.6879 mL 1.3758 mL 3.4395 mL
30 mM 0.1146 mL 0.5732 mL 1.1465 mL 2.8662 mL
40 mM 0.0860 mL 0.4299 mL 0.8599 mL 2.1497 mL
50 mM 0.0688 mL 0.3439 mL 0.6879 mL 1.7197 mL
60 mM 0.0573 mL 0.2866 mL 0.5732 mL 1.4331 mL
80 mM 0.0430 mL 0.2150 mL 0.4299 mL 1.0748 mL
100 mM 0.0344 mL 0.1720 mL 0.3439 mL 0.8599 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Midodrine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Midodrine43218-56-0(±)-MidodrineAdrenergic ReceptorBeta ReceptorAdrenergic receptorα1-receptorHypotensionC2C12HL1HepG2Inhibitorinhibitorinhibit

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