Midodrine-d6 hydrochloride
Based on 1 Customer Validation
Midodrine-d6 (hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine-d6 (hydrochloride) can strengthen vascular contraction. Midodrine-d6 (hydrochloride) can be used for the researches of cardiovascular disease, such as orthostatic hypotension.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 1188265-43-1
- Formula: C12H13D6ClN2O4
- Molecular Weight:296.78
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Midodrine-d6 (hydrochloride) (30 μM, 0-24 h) increases p-AMPK and PPARδ expression in C2C12, HL1 and HepG2 cells[3].
Midodrine-d6 (hydrochloride) (30 μM, 0-1 min) increases Ca2+ in C2C12, HL1 and HepG2 cells[3].
Midodrine-d6 (hydrochloride) (30 μM) increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells[3].
Midodrine-d6 (hydrochloride) (30-100 μM) reduces cellular lipid content in 3T3-L1 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12, HL1 and HepG2 cells
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Concentration:30 μM
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Incubation Time:0, 0.5, 1, 3, 6, and 24 h
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Result:Increased p-AMPK and PPARδ expression.
Midodrine-d6 (hydrochloride) (5 mg/kg, i.g.) shows anti-hypotensive effects in orthostatic hypotension rats models[2].
Midodrine-d6 (hydrochloride) (0.3 mg/kg, p.o., 4 weeks.) relieves hypertension in spontaneously hypertensive rats models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Orthostatic hypotension rats models[2]
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Dosage:5 mg/kg
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Administration:Orally gavage
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Result:Remarkably increased the baselines of SBP, DBP and MAP, but decreased HR.
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Animal Model:Spontaneously hypertensive rats models[3]
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Dosage:0.3 mg/kg
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Administration:Orally administration, 4 weeks
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Result:Increased p-AMPK, PPARδ and PGC-1α expression.
Increased SDH activity and ATP levels.
Increased expression of uncoupling protein 3 (UCP3).
Decreased left ventricular mass and the harvested cardiac weight.
Reduced both systolic and diastolic BP after 1 week.
Reduced serum total cholesterol, LDL cholesterol, and HDL cholesterol.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1188265-43-1
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Unlabeled Cas 43218-56-0
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Appearance Solid
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Molecular Weight 296.78
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Formula C12H13D6ClN2O4
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Color White to off-white
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SMILES
OC(CNC(CN)=O)C1=CC(OC([2H])([2H])[2H])=CC=C1OC([2H])([2H])[2H].[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (336.95 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
[1]. Criscuoli M, et al. Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. Br J Pharmacol. 1988 Jan;93(1):132-8. [Content Brief]
[2]. Inchan A, et al. Anti-hypotensive effect of "Yahom Navakot" in rats with orthostatic hypotension. J Tradit Complement Med. 2021 Aug 3;12(2):180-189. [Content Brief]
[3]. Lee YJ, et al. Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ. PPAR Res. 2020 Feb 1;2020:3785137. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.3695 mL | 16.8475 mL | 33.6950 mL | 84.2375 mL |
| 5 mM | 0.6739 mL | 3.3695 mL | 6.7390 mL | 16.8475 mL | |
| 10 mM | 0.3369 mL | 1.6847 mL | 3.3695 mL | 8.4237 mL | |
| 15 mM | 0.2246 mL | 1.1232 mL | 2.2463 mL | 5.6158 mL | |
| 20 mM | 0.1685 mL | 0.8424 mL | 1.6847 mL | 4.2119 mL | |
| 25 mM | 0.1348 mL | 0.6739 mL | 1.3478 mL | 3.3695 mL | |
| 30 mM | 0.1123 mL | 0.5616 mL | 1.1232 mL | 2.8079 mL | |
| 40 mM | 0.0842 mL | 0.4212 mL | 0.8424 mL | 2.1059 mL | |
| 50 mM | 0.0674 mL | 0.3369 mL | 0.6739 mL | 1.6847 mL | |
| 60 mM | 0.0562 mL | 0.2808 mL | 0.5616 mL | 1.4040 mL | |
| 80 mM | 0.0421 mL | 0.2106 mL | 0.4212 mL | 1.0530 mL | |
| 100 mM | 0.0337 mL | 0.1685 mL | 0.3369 mL | 0.8424 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Midodrine-d6 hydrochloride Related Classifications
HY-12749AS Related Classifications
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