Midodrine hydrochloride
Based on 1 Customer Validation
Midodrine hydrochloride ((±)-Midodrine hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine hydrochloride can strengthen vascular contraction. Midodrine hydrochloride can be used for the researches of cardiovascular disease, such as orthostatic hypotension.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 43218-56-0
- Formula: C12H19ClN2O4
- Molecular Weight:290.74
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Adrenergic Receptor Isoforms
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Biological Activity
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α adrenergic receptor |
Midodrine hydrochloride (30 μM, 0-24 h) increases p-AMPK and PPARδ expression in C2C12, HL1 and HepG2 cells[3].
Midodrine hydrochloride (30 μM, 0-1 min) increases Ca2+ in C2C12, HL1 and HepG2 cells[3].
Midodrine hydrochloride (30 μM) increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells[3].
Midodrine hydrochloride (30-100 μM) reduces cellular lipid content in 3T3-L1 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C2C12, HL1 and HepG2 cells
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Concentration:30 μM
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Incubation Time:0, 0.5, 1, 3, 6, and 24 h
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Result:Increased p-AMPK and PPARδ expression.
Midodrine hydrochloride (5 mg/kg, i.g.) shows anti-hypotensive effects in orthostatic hypotension rats models[2].
Midodrine hydrochloride (0.3 mg/kg, p.o., 4 weeks.) relieves hypertension in spontaneously hypertensive rats models[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Orthostatic hypotension rats models[2]
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Dosage:5 mg/kg
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Administration:Orally gavage
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Result:Remarkably increased the baselines of SBP, DBP and MAP, but decreased HR.
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Animal Model:Spontaneously hypertensive rats models[3]
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Dosage:0.3 mg/kg
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Administration:Orally administration, 4 weeks
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Result:Increased p-AMPK, PPARδ and PGC-1α expression.
Increased SDH activity and ATP levels.
Increased expression of uncoupling protein 3 (UCP3).
Decreased left ventricular mass and the harvested cardiac weight.
Reduced both systolic and diastolic BP after 1 week.
Reduced serum total cholesterol, LDL cholesterol, and HDL cholesterol.
Chemical Information
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CAS No. 43218-56-0
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Appearance Solid
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Molecular Weight 290.74
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Formula C12H19ClN2O4
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Color White to yellow
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SMILES
O=C(NCC(C1=CC(OC)=CC=C1OC)O)CN.[H]Cl
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Synonyms
(±)-Midodrine hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 100 mg/mL (343.95 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
[1]. Criscuoli M, et al. Catecholamines released from the adrenal medulla exert a compensatory, protective effect at beta 2-adrenoceptors against Paf-induced death in mice. Br J Pharmacol. 1988 Jan;93(1):132-8. [Content Brief]
[2]. Inchan A, et al. Anti-hypotensive effect of "Yahom Navakot" in rats with orthostatic hypotension. J Tradit Complement Med. 2021 Aug 3;12(2):180-189. [Content Brief]
[3]. Lee YJ, et al. Stimulation of Alpha1-Adrenergic Receptor Ameliorates Cellular Functions of Multiorgans beyond Vasomotion through PPARδ. PPAR Res. 2020 Feb 1;2020:3785137. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.4395 mL | 17.1975 mL | 34.3950 mL | 85.9875 mL |
| 5 mM | 0.6879 mL | 3.4395 mL | 6.8790 mL | 17.1975 mL | |
| 10 mM | 0.3439 mL | 1.7197 mL | 3.4395 mL | 8.5987 mL | |
| 15 mM | 0.2293 mL | 1.1465 mL | 2.2930 mL | 5.7325 mL | |
| 20 mM | 0.1720 mL | 0.8599 mL | 1.7197 mL | 4.2994 mL | |
| 25 mM | 0.1376 mL | 0.6879 mL | 1.3758 mL | 3.4395 mL | |
| 30 mM | 0.1146 mL | 0.5732 mL | 1.1465 mL | 2.8662 mL | |
| 40 mM | 0.0860 mL | 0.4299 mL | 0.8599 mL | 2.1497 mL | |
| 50 mM | 0.0688 mL | 0.3439 mL | 0.6879 mL | 1.7197 mL | |
| 60 mM | 0.0573 mL | 0.2866 mL | 0.5732 mL | 1.4331 mL | |
| 80 mM | 0.0430 mL | 0.2150 mL | 0.4299 mL | 1.0748 mL | |
| 100 mM | 0.0344 mL | 0.1720 mL | 0.3439 mL | 0.8599 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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