2. Apoptosis Metabolic Enzyme/Protease
  3. Ferroptosis Endogenous Metabolite
  4. NADPH tetrasodium salt

β-NADPH  (Synonyms: NADPH (tetrasodium salt))

製品番号: HY-F0003 純度: 99.98%
COA 取扱説明書 Technical Support

NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication.

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CAS 番号 : 2646-71-1

容量 価格（税別） 在庫状況 数量
50 mg $60 在庫あり
100 mg $96 在庫あり
250 mg $221 在庫あり
500 mg $377 在庫あり
1 g $640 在庫あり
5 g $1600 在庫あり
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カスタマーレビュー

Based on 18 publication(s) in Google Scholar

Other Forms of NADPH tetrasodium salt:

β-NADPH 関連抗体

Top Publications Citing Use of Products

    NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283.  [Abstract]

    A normal cellular state was recovered by adding TEMPO or NADPH (1mM, 24h), or SLC7A11 knockdown.

    NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283.  [Abstract]

    Western Blot analysis of RAC/WAVE pathway-related indicators in vitro skeletal muscle cells. Muscle cells treated with different condition NADPH(1mM, 24h).

    NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 15:e07283.  [Abstract]

    mtROS fluorescence staining of skeletal muscle cells in vitro. Muscle cells treated with different condition NADPH(1mM, 24h).

    NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Mol Plant Pathol. 2025 Dec;26(12):e70196.  [Abstract]

    Enzymatic activities of AtCAD7, AtCAD5, EcYahK, and EcYjgB toward (Z)‐3‐hexenal, acrolein, isovaleraldehyde, salicylaldehyde, and p‐coumaryl aldehyde. No Substrate was negative control. Assays were conducted under standardised conditions (30°C, pH 6.5, 100 μM substrate, 200 μM NADPH).

    NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878.  [Abstract]

    Apoptosis proportion of oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM) or NADH. Data are presented as the mean ± SD (n=3).

    NADPH tetrasodium salt purchased from MedChemExpress. Usage Cited in: Mol Ther Oncol. 2024 Sep 17;32(4):200878.  [Abstract]

    Western blotting detection of the expressions of caspase-3 and caspase-9 in oncoVV or oncoVV-AVL-treated AsPC-1(Up) and PANC-1 (Down) cells treated with NADPH (300 μM).

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

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    製品説明

    NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication[1][2][3][4].

    IC50 & Target[1]

    Human Endogenous Metabolite

     

    体外実験

    The regeneration rate of NADPH tetrasodium salt is often the rate-limiting step for the over-production of desired chemicals, while maintaining robust cellular growth[2].
    NADPH tetrasodium salt homeostasis is regulated by varied signaling pathways and several metabolic enzymes that undergo adaptive alteration in cancer cells. The metabolic reprogramming of NADPH tetrasodium salt renders cancer cells both highly dependent on this metabolic network for antioxidant capacity and more susceptible to oxidative stress[3].
    NADPH tetrasodium salt is an essential intracellular reductant needed to eliminate lipid hydroperoxides. Indeed, NADPH tetrasodium salt levels are a biomarker of ferroptosis sensitivity across many cancer cell lines[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    β-NADPH 関連抗体
    分子量

    833.35

    分子式

    C21H26N7Na4O17P3
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O[C@H]1[C@@H](O)[C@H](N2C=C(C(N)=O)CC=C2)O[C@@H]1COP(OP(OC[C@@H]3[C@@H](O)[C@@H](OP(O[Na])(O[Na])=O)[C@H](N(C4=NC=N5)C=NC4=C5N)O3)(O[Na])=O)(O[Na])=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, stored under nitrogen, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 125 mg/mL (150.00 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2000 mL 5.9999 mL 11.9998 mL
    5 mM 0.2400 mL 1.2000 mL 2.4000 mL
    10 mM 0.1200 mL 0.6000 mL 1.2000 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

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    体内:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (120.00 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.99%

    COA (263 KB) HNMR (317 KB) RP-HPLC (256 KB) MS (71 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.2000 mL 5.9999 mL 11.9998 mL 29.9994 mL
    5 mM 0.2400 mL 1.2000 mL 2.4000 mL 5.9999 mL
    10 mM 0.1200 mL 0.6000 mL 1.2000 mL 2.9999 mL
    15 mM 0.0800 mL 0.4000 mL 0.8000 mL 2.0000 mL
    20 mM 0.0600 mL 0.3000 mL 0.6000 mL 1.5000 mL
    25 mM 0.0480 mL 0.2400 mL 0.4800 mL 1.2000 mL
    30 mM 0.0400 mL 0.2000 mL 0.4000 mL 1.0000 mL
    40 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7500 mL
    50 mM 0.0240 mL 0.1200 mL 0.2400 mL 0.6000 mL
    60 mM 0.0200 mL 0.1000 mL 0.2000 mL 0.5000 mL
    80 mM 0.0150 mL 0.0750 mL 0.1500 mL 0.3750 mL
    100 mM 0.0120 mL 0.0600 mL 0.1200 mL 0.3000 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    NADPH tetrasodium salt Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    NADPH tetrasodium2646-71-1FerroptosisEndogenous MetabolitecofactormetabolicbiosyntheticpathwayslipidnucleotidesproteinsfattyacidsInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-F0003
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