2. Anti-infection
  3. Bacterial Antibiotic
  4. Nisin

Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity.

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カスタムペプチド

CAS 番号 : 1414-45-5

容量 価格（税別） 在庫状況 数量
100 mg $25 在庫あり
500 mg $40 在庫あり
1 g $60 在庫あり
5 g $120 在庫あり
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

ナイシン 関連抗体

Top Publications Citing Use of Products

    Nisin purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Jul 15:473:134536.

    Nisin (6-60 nM) greatly diminished growth and biosensor performance of L. lactis NZ9000.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity[1][2][3].

    体外実験

    Nisin (100-800 μg/mL, 36 h) inhibits HNSCC cell ballooning[1].
    Nisin (500-7000 IU/mL, 24 h) induces free-living amoeba acanthamoeba cell cycle arrest[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ナイシン 関連抗体

    Cell Viability Assay[2]

    Cell Line: A. castellanii trophozoites
    Concentration: 500, 1000, 2000, 3000, 4000, 6000, 7000 IU/mL
    Incubation Time: 24, 72 h
    Result: Inhibited amebic growth in a concentration-dependent manner at 24 h.

    Cell Cycle Analysis[2]

    Cell Line: A. castellanii trophozoites
    Concentration: 7000 IU/mL
    Incubation Time: 24 h
    Result: Increased S phase to 13.3% and the percentage of G1 to 11.1%.
    体内実験

    Nisin (25 mg/kg, intraperitoneally injected for 7 days) reduces uterine inflammation in rats by regulating the concentration of pro-inflammatory and anti-inflammatory cytokines[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Rat uterine endometritis model[3]
    Dosage: 25 mg/kg
    Administration: i.p. for 7 days
    Result: Decreased the endometritis-induced increase in uterine weight, restored endometrial architecture.
    Improved levels of B7-2, IFN-γ, IL-2 and IL-8.
    臨床実験
    分子量

    3354.07

    分子式

    C143H230N42O37S7
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to light brown

    Sequence

    Ile-Dhb-Ala-Ile-Dha-Leu-Ala-Abu-Pro-Gly-Ala-Lys-Abu-Gly-Ala-Leu-Met-Gly-Ala-Asn-Met-Lys-Abu-Ala-Aba-Ala-His-Ala-Ser-Ile-His-Val-Dha-Lys (Sulfide bridge: Ala3-Ala7, Abu8-Ala11, Abu13-Ala19, Abu23-Ala26, Aba25-Ala28)
    Sequence Shortening

    I-Dhb-AI-Dha-LA-Abu-PGAK-Abu-GALMGANMK-Abu-A-Aba-AHASIHV-Dha-K (Sulfide bridge: Ala3-Ala7, Abu8-Ala11, Abu13-Ala19, Abu23-Ala26, Aba25-Ala28)
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    polypeptide, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light)
    溶剤 & 溶解度
    体外: 

    H2O : 6.67 mg/mL (1.99 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.2981 mL 1.4907 mL 2.9815 mL
    5 mM --- --- ---
    10 mM --- --- ---
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    COA (275 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 0.2981 mL 1.4907 mL 2.9815 mL 7.4536 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Nisin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Nisin1414-45-5BacterialAntibioticHNSCCRat uterine endometritisAnti-inflammatoryA. castellanii trophozoitesInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-P1607
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