2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-Z8754
    Tacrolimus 8-epimer 129212-35-7
    Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone, an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.
    Tacrolimus 8-epimer
  • HY-10001R
    Calcipotriol (Standard) 112965-21-6 99.43%
    Calcipotriol (Standard) is the analytical standard of Calcipotriol. This product is intended for research and analytical applications. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.
    Calcipotriol (Standard)
  • HY-100118
    BW-A 78U 101155-02-6 99.67%
    BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM.
    BW-A 78U
  • HY-10011A
    (S)-SCH 563705 99.94%
    (S)-SCH 563705 is a S-enantiomer of SCH 563705. SCH 563705 (compound 16) is a potent and orally available CXCR2 and CXCR1 antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively.
    (S)-SCH 563705
  • HY-100152
    Beperidium iodide 86434-57-3 99.97%
    Beperidium iodide shows a competitive antagonistic effect against acetylcholine receptor with a pA2 of 7.93.
    Beperidium iodide
  • HY-100164
    SDZ-MKS 492 114606-56-3 99.77%
    SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats.
    SDZ-MKS 492
  • HY-100269
    Chymase-IN-1 862090-74-2 99.17%
    Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
    Chymase-IN-1
  • HY-100516
    Cimicoxib 265114-23-6 98.02%
    Cimicoxib (UR-8880) is an orally active, blood-brain barrier-permeable COX-2 inhibitor that also exerts targeted inhibition on CYP2D15. It has an IC50 of 66 nM against hCOX-2, an IC50 of 1.6 μM against canine CYP2D15, and an IC50 of 0.056 μM against feline CYP2D15. By inhibiting the COX-2 pathway to reduce the production of thromboxane B2 and prostaglandin E2, Cimicoxib exerts antipyretic, anti-inflammatory and analgesic effects. Cimicoxib is metabolized by CYP2D15 to form demethyl-cimicoxib, undergoes glucuronidation via UDP-glucuronosyltransferases, and exhibits biphasic elimination kinetics in beagle dogs. Cimicoxib is widely used in studies of inflammatory diseases, osteoarthritis, and perioperative pain associated with orthopedic or soft tissue surgeries.
    Cimicoxib
  • HY-100574
    Cl-amidine 913723-61-2 98%
    Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine induces apoptosis in cancer cells. Cl-amidine induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model.
    Cl-amidine
  • HY-100827
    Safotibant 633698-99-4 98.88%
    Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model.
    Safotibant
  • HY-100850
    Piperoxan hydrochloride 135-87-5 99.66%
    Piperoxan (Benodaine) hydrochloride is an α2 adrenoceptor antagonist. Piperoxan hydrochloride is the first-generation antihistamine.
    Piperoxan hydrochloride
  • HY-101015
    (2E)-OBAA 221632-26-4 98%
    (2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM.
    (2E)-OBAA
  • HY-101058
    PD1-PDL1-IN 1 2005454-12-4 98%
    PD1-PDL1-IN 1 (compound 16) is a potent programmed cell death 1 (PD-1) inhibitor. PD1-PDL1-IN 1 is useful as immune modulator.
    PD1-PDL1-IN 1
  • HY-101251
    AMT hydrochloride 21463-31-0 99.74%
    AMT hydrochloride is a selective inhibitor of inducible NOS (iNOS) with Ki of 4.2 nM.
    AMT hydrochloride
  • HY-101273
    BAR502 1612191-86-2 99.53%
    BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.
    BAR502
  • HY-101276
    AZD-1236 459814-89-2 99.62%
    AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12.
    AZD-1236
  • HY-101311
    UPF-523 168560-79-0 ≥98.0%
    UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis.
    UPF-523
  • HY-101427
    Bamaquimast 135779-82-7 98.97%
    Bamaquimast (F 10126) is an anti-asthmatic agent and mediator release inhibitor. Bamaquimast can be used in the research of chronic obstructive bronchopulmonary disease.
    Bamaquimast
  • HY-101458
    IT1t 864677-55-4 98%
    IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM.
    IT1t
  • HY-101526
    GENZ-882706 2070864-35-4 98%
    GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1.
    GENZ-882706
Cat. No. Product Name / Synonyms Application Reactivity