Safotibant
Based on 1 Customer Validation
Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.88%
- CAS 番号: 633698-99-4
- 分子式: C25H34N4O5S
- 分子量:502.63
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-15043
ELN-441958 -
HY-108896
Icatibant acetate -
HY-15039
SSR240612 -
HY-P0206A
Bradykinin acetate -
HY-P1490
Bradykinin (2-9) -
HY-P0206
Bradykinin -
HY-17446
Icatibant -
HY-108896R
Icatibant acetate (Standard) -
HY-105155
Lobradimil -
HY-P4676
Lys-(Des-Arg9,Leu8)-Bradykinin -
HY-P1469
Bradykinin (1-6) -
![Sar-[D-Phe8]-des-Arg9-Bradykinin](https://file.medchemexpress.com/product_pic/hy-103291.gif)
HY-103291
Sar-[D-Phe8]-des-Arg9-Bradykinin
Bradykinin Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体内実験
Safotibant (one eye drop application, twice a day for 7 days) inhibits expressions of inflammatory mediators B1R, iNOS, IL-1β, COX-2, VEGF-R2 and HIF-1α, reverses diabetes-induced retinal inflammation and oxidative stress in streptozotocin (STZ)-diabetic Wistar rats model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Osteolytic sarcoma xenograft C3H/HeJ mice model[1]
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Dosage:10 mg/kg
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Administration:s.c., 3 times a day for 8 days
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Result:Decreased numbers of flinching and time spent on spontaneous guarding.
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Animal Model:Streptozotocin (STZ)-diabetic Wistar rats model[2]
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Dosage:One eye drop
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Administration:On eyes application, twice a day for 7 days
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Result:Reversed retinal vascular hyperpermeability, decreased levels of retinal leukostasis and superoxide anion in 3 retinal nuclear layers.
化学情報
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CAS 番号 633698-99-4
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性状 Oil
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分子量 502.63
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分子式 C25H34N4O5S
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Color White to light yellow
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SMILES
O=C(COCCN(S(=O)(C1=C(C)C=C(OC)C=C1C)=O)C)N(CC2=CC=C(C3=NCCN3)C=C2)C
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別名
LF22-0542
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Sevcik MA, et al., Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model. J Pain. 2005 Nov;6(11):771-5. [Content Brief]
[2]. Pouliot M, et al., Ocular application of the kinin B1 receptor antagonist LF22-0542 inhibits retinal inflammation and oxidative stress in streptozotocin-diabetic rats. PLoS One. 2012;7(3):e33864. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Safotibant 関連分類
HY-100827 関連分類
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