633698-99-4
Chemical Structure
Safotibant
Synonym(s): LF22-0542
- CAS No.: 633698-99-4
- Formula:C25H34N4O5S
- Molecular Weight:502.63
IUPAC Name: N-(4-(4,5-dihydro-1H-imidazol-2-yl)benzyl)-2-(2-((4-methoxy-N,2,6-trimethylphenyl)sulfonamido)ethoxy)-N-methylacetamide
InChIKey: AMTQCENHQIDBHQ-UHFFFAOYSA-N
SMILES: O=C(COCCN(S(=O)(C1=C(C)C=C(OC)C=C1C)=O)C)N(CC2=CC=C(C3=NCCN3)C=C2)C
Biological Activity: Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model[1][2].
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Safotibant | 98.88% | Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model. | ||||||||||||||||||||
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- [1]. Sevcik MA, et al., Analgesic efficacy of bradykinin B1 antagonists in a murine bone cancer pain model. J Pain. 2005 Nov;6(11):771-5. [Content Brief]
- [2]. Pouliot M, et al., Ocular application of the kinin B1 receptor antagonist LF22-0542 inhibits retinal inflammation and oxidative stress in streptozotocin-diabetic rats. PLoS One. 2012;7(3):e33864. [Content Brief]
Keywords
