2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-112575
    Tiazotic acid 64679-65-8
    Tiazotic acid is a metabolic agent that has immunomodulatory, anti-inflammatory, antioxidant, anti-ischemic, cardio- and endothelioprotective, antiplatelet, hepatoprotective activities. Tiazotic acid increases the levels of eNOS. Tiazotic acid also reduces the level of D-dimer in the blood, which reduces the risks of heart attacks and strokes in post-COVID syndrome.
    Tiazotic acid
  • HY-112736
    RG 14893 141835-49-6 98%
    RG 14893 is a high affinity, competitive, orally active leukotriene B4 receptor antagonist.
    RG 14893
  • HY-112738
    AX048 873079-69-7 98%
    AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA2 with a XI(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy.
    AX048
  • HY-112739
    SC-41930 120072-59-5 98%
    SC-41930 is a orally active eukotriene-B4 receptor antagonist. SC-41930 alleviates inflammation in guinea pig acetic acid-induced colonic inflammation model.
    SC-41930
  • HY-112740
    SC-53228 153633-01-3 98%
    SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis.
    SC-53228
  • HY-112742
    CP-195543 204981-48-6 98.86%
    CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC50s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration.
    CP-195543
  • HY-112783
    TYK2 ligand 4 1258295-27-0 98%
    TYK2 ligand 4 (Compound 2) is a TYK2 ligand. TYK2 ligand 4 binds to both the kinase domain and pseudokinase domain, and induces an inactive conformation of the kinase domain, thereby preventing ATP binding. TYK2 ligand 4 serves as a tool compound for the development of Deucravacitinib (HY-117287).
    TYK2 ligand 4
  • HY-112828
    LEI105 1800327-36-9 98%
    LEI105 is a potent, highly selective and reversible dual diacylglycerol lipase (DAGL)-α/DAGL-β inhibitor. LEI105 reduces 2-arachidonoylglycerol levels in Neuro2A cells. LEI105 also reduces cannabinoid CB1-receptor-mediated short-term synaptic plasticity in a mouse hippocampal slice model. LEI105 is promising for research of diseases, such as obesity, related metabolic disorders and neuroinflammation.
    LEI105
  • HY-112864
    TGFβRI-IN-6 2072051-04-6 98%
    TGFβRI-IN-6 (compound 22) is a potent TGFβRI inhibitor with an IC50 value of 0.55 nM. TGFβRI-IN-6 has the potential to enhance anti-tumor immunity.
    TGFβRI-IN-6
  • HY-112894
    ZG-10 1408077-04-2 98%
    ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent.
    ZG-10
  • HY-112946
    LU-001i 1620107-60-9 98%
    LU-001i is a highly specific proteasome β1i (LMP2) inhibitor. LU-001i alone has no significant immunomodulatory effect, but when combined with the LMP7 inhibitor (PRN1126), it can exert anti-inflammatory and immunomodulatory effects. LU-001i can be used for the study of autoimmune diseases.
    LU-001i
  • HY-113001
    LysoPC(20:3(8Z,11Z,14Z)/0:0) 1006703-11-2 98%
    LysoPC (20:3 (8Z,11Z,14Z)/0:0) is a bioactive lysophosphatidylcholine. LysoPC (20:3 (8Z,11Z,14Z)/0:0) is applicable to research related to inflammation and autoimmune diseases.
    LysoPC(20:3(8Z,11Z,14Z)/0:0)
  • HY-113111
    11,12-DiHETrE 192461-95-3 98%
    11,12-DiHETrE is a dihydroxy fatty acid metabolite of Arachidonic Acid (HY-109590). 11,12-DiHETrE is converted to 11,12-DiHETrE under elevated soluble epoxide hydrolase (sEH) activity, a process closely related to inflammation and oxidative stress. 11,12-DiHETrE can serve as a single biomarker to differentiate between NAFL (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis). 11,12-DiHETrE can be used in studies on preterm birth, autism, and pulmonary hypertension.
    11,12-DiHETrE
  • HY-113271
    5-Androstenetriol 4150-30-5 98%
    5-Androstenetriol is a systemic radiation protector that can boost the host's immunity, leading to increased resistance to infections. 5-Androstenetriol can raise levels of IL-2, IL-3, and IFN, while countering the immunosuppressive effects of Hydrocortisone (HY-N0583).
    5-Androstenetriol
  • HY-113355
    NADH 58-68-4 98%
    NADH is an orally active dehydrogenase coenzyme that acts as a crucial electron carrier in cellular respiration and participates in ATP production. NADH promotes metabolism, supports brain function, and counteracts oxidative stress by transferring electrons to the electron transport chain. As a signaling molecule, NADH regulates multiple biological processes, including anti-apoptosis, synaptic plasticity, gene expression, and calcium homeostasis. Redox imbalance of NADH/NAD⁺ is one of the key pathological mechanisms of various diseases, such as diabetic nephropathy, neurodegenerative diseases, and ischemia-reperfusion injury.
    NADH
  • HY-113359
    Uridine 5'-diphosphate 58-98-0 98%
    Uridine 5'-diphosphate (UDP) is a P2Y6 receptor agonist with an EC50 of 0.013 μM for human P2Y6 receptor.
    Uridine 5'-diphosphate
  • HY-113442
    6-trans-12-epi-Leukotriene B4 71548-19-1 98%
    6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent.
    6-trans-12-epi-Leukotriene B4
  • HY-113460
    11-trans-Leukotriene C4 74841-69-3 98%
    11-trans-Leukotriene C4 is trans-Leukotriene C4 (LTC4). LTC4 is an important inflammatory mediator and regulator of allergic responses.
    11-trans-Leukotriene C4
  • HY-113479
    20-Hydroxy-leukotriene B4 79516-82-8 98%
    20-Hydroxy-leukotriene B4 is an endogenous metabolite present in Urine that can be used for the research of Sjogren Larsson Syndrome.
    20-Hydroxy-leukotriene B4
  • HY-113589
    ICI 198615 104448-53-5 98%
    ICI 198615 is a lipoxygenase inhibitor. ICI 198615 inhibits the activity of lipoxygenases involved in eicosanoid metabolism. ICI 198615 attenuates the early phase of bronchoconstriction induced by ET-1.
    ICI 198615
Cat. No. Product Name / Synonyms Application Reactivity