2. Metabolic Enzyme/Protease
  3. Proteasome
  4. LU-001i

LU-001i is a highly specific proteasome β1i (LMP2) inhibitor. LU-001i alone has no significant immunomodulatory effect, but when combined with the LMP7 inhibitor (PRN1126), it can exert anti-inflammatory and immunomodulatory effects. LU-001i can be used for the study of autoimmune diseases.

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LU-001i

LU-001i Chemical Structure

CAS No. : 1620107-60-9

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LU-001i Related Antibodies

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Description

LU-001i is a highly specific proteasome β1i (LMP2) inhibitor. LU-001i alone has no significant immunomodulatory effect, but when combined with the LMP7 inhibitor (PRN1126), it can exert anti-inflammatory and immunomodulatory effects. LU-001i can be used for the study of autoimmune diseases[1].

Cellular Effect
Cell Line Type Value Description References
RPMI-8226 IC50
0.13 μM
Compound: 37, LU-001i
Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
[PMID: 25006746]
RPMI-8226 IC50
47 μM
Compound: 37, LU-001i
Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry
[PMID: 25006746]
RPMI-8226 IC50
65 μM
Compound: 37, LU-001i
Inhibition of proteasome subunit beta-5c/i in human RPMI8226 cells by fluorescent densitometry
Inhibition of proteasome subunit beta-5c/i in human RPMI8226 cells by fluorescent densitometry
[PMID: 25006746]
RPMI-8226 IC50
> 100 μM
Compound: 37, LU-001i
Inhibition of proteasome subunit beta-2c/i in human RPMI8226 cells by fluorescent densitometry
Inhibition of proteasome subunit beta-2c/i in human RPMI8226 cells by fluorescent densitometry
[PMID: 25006746]
Raji IC50
0.095 μM
Compound: 37, LU-001i
Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
[PMID: 25006746]
Raji IC50
24 μM
Compound: 37, LU-001i
Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
[PMID: 25006746]
Raji IC50
> 100 μM
Compound: 37, LU-001i
Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry
[PMID: 25006746]
Molecular Weight

611.68

Formula

C28H43F2N7O6
CAS No.
SMILES

O=C([C@@H]1CC(F)(F)CN1C([C@@H](NC(CN=[N+]=[N-])=O)C)=O)N[C@@H](CCCC)C(N[C@@H](CC2CCCCC2)C([C@]3(C)OC3)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LU-001i Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LU-001i1620107-60-9ProteasomeCo-inhibitionImmunoproteasome LMP7(β5i)inhibitorInhibitorinhibitorinhibit

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