1620107-60-9
Chemical Structure
LU-001i
- CAS No.: 1620107-60-9
- Formula:C28H43F2N7O6
- Molecular Weight:611.68
IUPAC Name: (S)-1-((2-azidoacetyl)-L-alanyl)-N-((S)-1-(((S)-3-cyclohexyl-1-((R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)amino)-1-oxohexan-2-yl)-4,4-difluoropyrrolidine-2-carboxamide
InChIKey: BYGWQGGWZMNGGA-MDEFBCHOSA-N
SMILES: O=C([C@@H]1CC(F)(F)CN1C([C@@H](NC(CN=[N+]=[N-])=O)C)=O)N[C@@H](CCCC)C(N[C@@H](CC2CCCCC2)C([C@]3(C)OC3)=O)=O
Biological Activity: LU-001i is a highly specific proteasome β1i (LMP2) inhibitor. LU-001i alone has no significant immunomodulatory effect, but when combined with the LMP7 inhibitor (PRN1126), it can exert anti-inflammatory and immunomodulatory effects. LU-001i can be used for the study of autoimmune diseases[1].
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LU-001i | LU-001i is a highly specific proteasome β1i (LMP2) inhibitor. LU-001i alone has no significant immunomodulatory effect, but when combined with the LMP7 inhibitor (PRN1126), it can exert anti-inflammatory and immunomodulatory effects. LU-001i can be used for the study of autoimmune diseases. | |||||||||||||||||||||
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