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Cat. No.: HY-113589

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ICI 198615

ICI 198615 is a lipoxygenase inhibitor. ICI 198615 inhibits the activity of lipoxygenases involved in eicosanoid metabolism. ICI 198615 attenuates the early phase of bronchoconstriction induced by ET-1.

For research use only. We do not sell to patients.

CAS No.: 104448-53-5
Formula: C₂₈H₂₈N₄O₆S
Molecular Weight:548.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ICI 198615 Chemical Structure

CAS No.: 104448-53-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
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Biological Activity

Description

All Lipoxygenase Isoforms :

In Vivo

ICI 198615 (0.1 µg/kg; i.v.; single dose) inhibits the early phase of ET-1-induced bronchoconstriction in anesthetized mongrel dogs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mongrel dogs (~20 kg; anesthetized)^[1]
Dosage:

0.1 µg/kg
Administration:

i.v.; single dose
Result:

Inhibited the early phase (measured at 2 minutes post-ET-1 exposure) of ET-1-induced increase in collateral resistance (Rcs).
Did not affect the late phase bronchoconstrictive response.

Chemical Information

CAS No. 104448-53-5
Molecular Weight 548.61
Formula C₂₈H₂₈N₄O₆S
SMILES

O=C(OC1CCCC1)NC2=CC3=C(C=C2)C=NN3CC4=CC=C(C(NS(=O)(C5=CC=CC=C5)=O)=O)C=C4OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Uchida Y, et al. ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615. Biochem Biophys Res Commun. 1992;183(3):1197-1202. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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ICI 198615

All Lipoxygenase Isoforms