ZG-10
ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent.
For research use only. We do not sell to patients.
- CAS No.: 1408077-04-2
- Formula: C28H27N7O2
- Molecular Weight:493.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
JNK1 809 nM (IC50) |
JNK2 1140 nM (IC50) |
JNK3 709 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
2.4 μM
Compound: 70
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Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation
Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation
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[PMID: 25415535] |
| HeLa | IC50 |
0.704 μM
Compound: 70
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Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation
Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation
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[PMID: 25415535] |
Chemical Information
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CAS No. 1408077-04-2
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Molecular Weight 493.56
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Formula C28H27N7O2
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SMILES
O=C(NC1=CC=C(C(NC2=CC(NC3=NC(C4=CN=CC=C4)=CC=N3)=CC=C2)=O)C=C1)/C=C/CN(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (264 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Tinghu Zhang, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. [Content Brief]
[2]. Rui Zhang, et al. Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium. Bioengineered. 2022 Feb;13(2):2486-2497. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZG-10 Related Classifications
HY-112894 Related Classifications
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