1408077-04-2
1408077-04-2
Chemical Structure
ZG-10
- CAS No.: 1408077-04-2
- Formula:C28H27N7O2
- Molecular Weight:493.56
IUPAC Name: (E)-4-(4-(dimethylamino)but-2-enamido)-N-(3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
InChIKey: VZEONOGFXYTZGT-WEVVVXLNSA-N
SMILES: O=C(NC1=CC=C(C(NC2=CC(NC3=NC(C4=CN=CC=C4)=CC=N3)=CC=C2)=O)C=C1)/C=C/CN(C)C
Biological Activity: ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent[1][2].
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ZG-10 | ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent. | |||||||||||||||||||||
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References
- [1]. Tinghu Zhang, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. [Content Brief]
- [2]. Rui Zhang, et al. Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium. Bioengineered. 2022 Feb;13(2):2486-2497. [Content Brief]
