2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-120440
    VT-ME6 1353880-00-8 98%
    VT-ME6 is a selective SphK2 inhibitor with a Ki of 8 µM. VT-ME6 can be used in the research of inflammatory diseases.
    VT-ME6
  • HY-120451
    Salvinone 124681-15-8 98%
    Salvinone (Compound 49) is a compound that can be isolated from Salvia miltiorrhiza.
    Salvinone
  • HY-120457
    WYE-151650 1141855-86-8 98%
    WYE-151650 is a selective JAK-3 inhibitor. WYE-151650 suppresses IL-2-induced STAT-5 phosphorylation and cell proliferation mediated by JAK-3. WYE-151650 is promising for research of autoimmune diseases.
    WYE-151650
  • HY-120460
    8(R)-HETE 105500-09-2 98%
    8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
    8(R)-HETE
  • HY-120468
    GSK2263167 1165924-28-6 98%
    GSK2263167 is a S1P1 receptor agonist
    GSK2263167
  • HY-12048R
    Chelerythrine chloride (Standard) 3895-92-9
    Chelerythrine (chloride) (Standard) is the analytical standard of Chelerythrine (chloride). This product is intended for research and analytical applications. Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
    Chelerythrine chloride (Standard)
  • HY-120492
    RS-21314 125709-03-7 98%
    RS-21314 is a thiol ester corticosteroid with anti-inflammatory effects.
    RS-21314
  • HY-120502
    5-LOX-IN-6 1159576-98-3 98%
    5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC50 values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research.
    5-LOX-IN-6
  • HY-120505
    ITZ-1 1180532-17-5 98%
    ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases.
    ITZ-1
  • HY-120510
    PF-04308515 1206876-95-0 98%
    PF-04308515 is a glucocorticoid receptor ligand. PF-04308515 inhibits IL-6, IFNγ production. PF-04308515 induces weak PGC1α interaction. PF-04308515 has antiinflammatory activities.
    PF-04308515
  • HY-120539
    Enofelast 125722-16-9 98%
    Enofelast (BI-L-239), a 5-lipoxygenase (5-LO) inhibitor, exhibits an IC50 of 2.48 μM for inhibition of calcium ionophore-induced LTB4 generation.
    Enofelast
  • HY-120544
    BAY-386 1256941-06-6 98%
    BAY-386, a chemical probe, is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC.
    BAY-386
  • HY-120580
    L 689037 136668-50-3 98%
    L 689037 is a leukotriene biosynthesis (LT) inhibitor and a 5-lipoxygenase-activating protein (FLAP) binder. [125I]-L 691,831 serves as a standard probe to precisely locate the key structural domains that determine the binding of inhibitors to FLAP. L 689037 can be used in the research of asthma and inflammatory bowel disease.
    L 689037
  • HY-120598
    ASP7657 free base 1196045-28-9 99.30%
    ASP7657 free base is an orally active EP4 receptor antagonist, with Kis of 2.21 and 6.02 nM for the human and rat EP4 receptors.
    ASP7657 free base
  • HY-120600
    Sibiriline 1346526-26-8 98%
    Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis..
    Sibiriline
  • HY-120611
    BMS-960 free base 1265321-86-5 98%
    BMS-960 free base is a potent and selective S1P1 receptor agonist containing isoxazole, which can be used in the research of immune diseases and vascular diseases.
    BMS-960 free base
  • HY-120615
    BMS-520 1236188-38-7 98%
    BMS-520 is a potent, orally active and selective sphingosine-1-phosphate 1 (S1P1) agonist with an EC50 of 0.47nM. BMS-520 shows ~3400-fold selectivity over S1P3. BMS-520 demonstrates impressive efficacy in a rat model of arthritis and in a mouse experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis. BMS-520 can be used for arthritis and EAE research.
    BMS-520
  • HY-120621
    BMS-229724 221914-85-8 98%
    BMS-229724 is an orally active and tight-binding cytosolic phospholipase A2 (cPLA2) inhibitor with an IC50 of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation.
    BMS-229724
  • HY-120624
    BMS-354326 708258-16-6 98%
    BMS-354326 is a tryptase inhibitor with an IC50 of 1.8 nM. BMS-354326 exhibits excellent selectivity against trypsin and most other related serine proteases. BMS-354326 can be used in the research of asthma and inflammatory diseases.
    BMS-354326
  • HY-120629
    BMS-639623 675122-44-8 98%
    BMS-639623 is a potent and orally activeCCR3 antagonist with an IC50 of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC50=38 pM). BMS-639623 can be used for the research of asthma.
    BMS-639623
Cat. No. Product Name / Synonyms Application Reactivity