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Cat. No.: HY-120544

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BAY-386

BAY-386, a chemical probe, is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC.

For research use only. We do not sell to patients.

CAS No.: 1256941-06-6
Formula: C₂₂H₂₅F₃N₄O₅S
Molecular Weight:514.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BAY-386 Chemical Structure

CAS No.: 1256941-06-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BAY-386, a chemical probe, is a PAR-1 antagonist that inhibits the expression of pro-inflammatory factors MCP-1 and CXCL1 in HUVEC^[1].

IC₅₀ & Target

PAR-1, CXCL1^[1]

All Protease Activated Receptor (PAR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	>100 μM Compound: EUB0000291	Inhibition of platelet aggregation (human plasma, ADP, Collagen) Inhibition of platelet aggregation (human plasma, ADP, Collagen)	10.6019/CHEMBL4507269
Platelet	IC₅₀	0.14 μM Compound: EUB0000291	Inhibition of platelet aggregation (human plasma, thrombin) Inhibition of platelet aggregation (human plasma, thrombin)	10.6019/CHEMBL4507269
Platelet	IC₅₀	0.43 μM Compound: EUB0000291	Inhibition of platelet aggregation (human plasma, TRAP-6) (IC50) Inhibition of platelet aggregation (human plasma, TRAP-6) (IC50)	10.6019/CHEMBL4507269

Chemical Information

CAS No. 1256941-06-6
Molecular Weight 514.52
Formula C₂₂H₂₅F₃N₄O₅S
SMILES

O=C(N1C[C@@H](C2=NC(C3CC3)=NO2)C[C@@H](C4=CC=C(OC(F)(F)F)C=C4)C1)N5CCS(CC5)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Santos S R F. Impact of PAR-1 upregulation upon EXT-1kd on balancing resistance and platelet activation[D]. Universidade de Lisboa (Portugal), 2022.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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BAY-386

All Protease Activated Receptor (PAR) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BAY-386 Related Classifications

HY-120544 Related Classifications