L 689037 

L 689037 is a leukotriene biosynthesis (LT) inhibitor and a 5-lipoxygenase-activating protein (FLAP) binder. [¹²⁵I]-L 691,831 serves as a standard probe to precisely locate the key structural domains that determine the binding of inhibitors to FLAP. L 689037 can be used in the research of asthma and inflammatory bowel disease^[1].

L 689037 competes with [¹²⁵I]-L-691,831 for binding to wild-type and select mutant human 5-lipoxygenase-activating protein expressed in COS-7 cell membranes with IC₅₀ values ranging from 2 nM to 41 nM, while binding is undetectable for mutants with deletions in residues 48-61^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

597.14

C₃₆H₃₇ClN₂O₄

136668-50-3

O=C(C(C)(CC(N1CC2=CC=C(C=C2)Cl)=C(C3=C1C=CC(OCC4=NC5=CC=CC=C5C=C4)=C3)C(CC(C)(C)C)=O)C)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mancini JA, et al. The binding of leukotriene biosynthesis inhibitors to site-directed mutants of human 5-lipoxygenase-activating protein. Life Sci. 1994;54(9):PL137-PL142.  [Content Brief]