BMS-639623
BMS-639623 is a potent and orally activeCCR3 antagonist with an IC50 of 0.3 nM. BMS-639623 picomolar inhibition potency against eosinophil chemotaxis (IC50=38 pM). BMS-639623 can be used for the research of asthma.
For research use only. We do not sell to patients.
- CAS No.: 675122-44-8
- Formula: C25H32FN7O2
- Molecular Weight:481.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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CCR3 0.3 nM (IC50) |
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.3 nM
Compound: 1, BMS-639623
|
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cells
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cells
|
[PMID: 18160284] |
| CHO | IC50 |
0.3 nM
Compound: 31, BMS-639623
|
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
|
[PMID: 18096386] |
| CHO | IC50 |
0.4 nM
Compound: 1, BMS-639623
|
Displacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cells
Displacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cells
|
[PMID: 18160284] |
| Eosinophil | IC50 |
0.038 nM
Compound: C, BMS-639623
|
Induction of shape change in human eosinophils by flow cytometry
Induction of shape change in human eosinophils by flow cytometry
|
[PMID: 19010676] |
Chemical Information
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CAS No. 675122-44-8
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Molecular Weight 481.57
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Formula C25H32FN7O2
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SMILES
O=C(NC1=CC=CC(C2=NN=NN2C)=C1)N[C@H](C)[C@@H](O)CN3C[C@H](CC4=CC=C(F)C=C4)CCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)