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Cat. No.: HY-120510

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PF-04308515

(Synonyms: PF 4308515)

PF-04308515 is a glucocorticoid receptor ligand. PF-04308515 inhibits IL-6, IFNγ production. PF-04308515 induces weak PGC1α interaction. PF-04308515 has antiinflammatory activities.

For research use only. We do not sell to patients.

CAS No.: 1206876-95-0
Formula: C₃₅H₃₄N₂O₄
Molecular Weight:546.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PF-04308515 Chemical Structure

CAS No.: 1206876-95-0

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Sample (0.1mg)

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(In Japan)

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PF-04308515 is a glucocorticoid receptor ligand. PF-04308515 inhibits IL-6, IFNγ production. PF-04308515 induces weak PGC1α interaction. PF-04308515 has antiinflammatory activities^[1].

IC₅₀ & Target^[1]

IL-6

All Interleukin Related Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1206876-95-0
Molecular Weight 546.66
Formula C₃₅H₃₄N₂O₄
SMILES

O=C(C(C=C12)=CC=C2[C@]3(CC4=CC=CC=C4)C[C@@](C)(O)[C@@](C5=CC=CC=C5)(O)C[C@@]3([H])CC1=O)NC6=CC=CN=C6C
Synonyms

PF 4308515
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu X, et al. The antagonists but not partial agonists of glucocorticoid receptor ligands show substantial side effect dissociation. Endocrinology. 2011 Aug;152(8):3123-34. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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