ITZ-1
ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases.
For research use only. We do not sell to patients.
- CAS No.: 1180532-17-5
- Formula: C20H20F5N3O3S3
- Molecular Weight:541.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1180532-17-5
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Molecular Weight 541.58
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Formula C20H20F5N3O3S3
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SMILES
O=S(C1=CC=C(C)C=C1)(/N=C(C2=C(SCCCC(F)(F)C(F)(F)F)SC(C)=C(C)N23)\NC3=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ITZ-1 Related Classifications
HY-120505 Related Classifications
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