2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N18029
    (24S)-Ginsenoside V 1679350-46-9
    (24S)-Ginsenoside V is a monooxygenated derivative of Ginsenoside Rb1 (HY-N0039). (24S)-Ginsenoside V is the major circulating metabolite of Ginsenoside Rb1 in rat plasma. (24S)-Ginsenoside V appears in rat urine after intravenous and oral administration of Ginsenoside Rb1 to rats.
    (24S)-Ginsenoside V
  • HY-N18031
    Idesin 20331-85-5
    Idesin is a compound found in the fruits of Idesia polycarpa. Idesin inhibits LPS (HY-D1056)-induced nitric oxide production with mild cytotoxicity.
    Idesin
  • HY-N18052
    Massonianoside E 872037-79-1 98%
    Massonianoside E is an antioxidant that has been found to be present in the fruits of Viburnum rhytidophyllum Hemsl. Massonianoside E can exert antioxidant activity in DPPH, ABTS and PTIO assays.
    Massonianoside E
  • HY-N18059
    Spiradine A 19741-46-9
    Spiradine A (6-Hydroxyhetisan-11-one) is a C20 diterpenoid alkaloid present in the roots of Thalictrum sessile (Ranunculaceae), and is originally isolated from Spiraea japonica (Rosaceae). Spiradine A may possess anti-inflammatory and analgesic activities.
    Spiradine A
  • HY-N18065
    Kuwanon Y 105016-28-2
    Kuwanon Y is a Diels-Alder type adduct with antioxidant activity. Kuwanon Y is present in the stem bark of Morus macroura Miq.
    Kuwanon Y
  • HY-N18066
    Esculeogenin A 854381-37-6 98%
    Esculeogenin A is the sapogenol of tomato saponin Esculeoside A (HY-N18067). Esculeogenin A is an orally active hepatoprotective, hypolipidemic, and antioxidant agent. Esculeogenin A regulates molecular targets like PPARα, SREBP1, Nrf2, NF-κB, ACAT1/ACAT2 to promote hepatic fatty acid oxidation, suppress de novo lipogenesis, enhance antioxidant defense, and inhibit inflammation. Esculeogenin A improves liver function, alleviates hyperlipidemia, and inhibits hepatic steatosis and foam cell formation, preventing nonalcoholic fatty liver disease in high-fat-diet-fed rats and reducing atherosclerotic lesions in apoE-deficient mice. Esculeogenin A can be used for the research of nonalcoholic fatty liver disease, atherosclerosis, and hyperlipidemia.
    Esculeogenin A
  • HY-N18070
    12-Deoxyphorbol-13-isobutyrate-20-acetate 25090-71-5 98%
    12-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection.
    12-Deoxyphorbol-13-isobutyrate-20-acetate
  • HY-N18080
    Parthenin 508-59-8 98%
    Parthenin is a pseudoguaianolide-type sesquiterpene lactone present in Parthenium hysterophorus L. Parthenin induces chromosomal aberrations, mainly chromatid breaks, in human peripheral blood lymphocytes. Parthenin exhibits toxicity against Salmonella typhimurium and Escherichia coli strains, with reduced toxicity in the presence of a metabolic activation system (S9). Parthenin acts as an antifeedant against the 6th instar larvae of the tobacco cutworm (Spodoptera litura). Parthenin shows insecticidal activity against adult cowpea weevils (Callosobruchus maculatus). Parthenin inhibits seed germination and seedling growth of sicklepod (Cassia tora). Parthenin possesses nematicidal activity against the 2nd instar larvae of the southern root-knot nematode (Meloidogyne incognita). Parthenin serves as a research agent for studies related to cancer, malaria, amoebiasis, inflammatory diseases, and bacterial infections.
    Parthenin
  • HY-N18091
    Tovophyllin A 40738-44-1 98%
    Tovophyllin A is an orally active xanthonoid compound. Tovophyllin A exerts neuroprotective effects against Parkinson's disease by activating the Akt/GSK3β signaling pathway. Tovophyllin A protects mouse models of liver injury by activating Nrf2. Tovophyllin A exhibits protective anti-inflammatory activity in mouse models of acute lung injury. Tovophyllin A inhibits the activation of NF-κB and subsequent release of pro-inflammatory cytokines. Tovophyllin A reduces apoptotic cell death (Apoptosis). Tovophyllin A has antiplasmodial activity. Tovophyllin A shows cytotoxic activity against lung epithelial cancer cells and breast cancer cells. Tovophyllin A can be used in research related to Parkinson's disease, liver injury, acute lung injury, lung epithelial cancer, and breast cancer.
    Tovophyllin A
  • HY-N18093
    5-Hydroxycoumarin 6093-67-0 98%
    5-Hydroxycoumarin is a monohydroxycoumarin compound that occurs in the stems of Alyxia lucida, a plant of the genus Alyxia (Apocynaceae).
    5-Hydroxycoumarin
  • HY-N18146
    14-Acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 129587-05-9 98%
    14-Acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol is an orally active acetylenic compound present in the rhizomes of Atractylodes macrocephala Koidz. 14-Acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol is applicable to the research of acute inflammation.
    14-Acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol
  • HY-N18171
    Caryophyllene 13877-93-5 98%
    Caryophyllene is a macrocyclic sesquiterpene alkene present in the essential oil of Artemisia annua, with anti-inflammatory and anticancer activities. Caryophyllene plays a role in the plant defense of Artemisia annua.
    Caryophyllene
  • HY-N18182
    Mudanpioside E 172705-25-8
    Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases.
    Mudanpioside E
  • HY-N18187
    Hirundigoside E 2192292-95-6 98%
    Hirundigoside E is a compound with anti-inflammatory activity. Hirundigoside E inhibits LPS (HY-D1056)-induced iNOS protein expression in macrophages. Hirundigoside E can be used for the research of inflammatory diseases.
    Hirundigoside E
  • HY-N18218
    Speranskoside 219917-70-1
    Speranskoside is a dual COX-2/15-LOX inhibitor with a COX-2 IC50 of 2.62 μg/mL and a 15-LOX IC50 of 5.51 μg/mL. Speranskoside can be used for the research of gastric ulcers.
    Speranskoside
  • HY-N18225
    β-Curcumene 451-56-9 98%
    β-Curcumene is a sesquiterpene compound. β-Curcumene has the potential to act as a SIRT1 activator and a NF-κB inhibitor. β-Curcumene possesses a spicy and ginger-like aroma, and can serve as a raw material for flavors, fragrances and cosmetics. β-Curcumene can be used in the research of type 2 diabetes.
    β-Curcumene
  • HY-N18235
    (1Z)-Atractylodinol 362673-12-9
    (1Z)-Atractylodinol, an acetylenes compound, is a weak 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases.
    (1Z)-Atractylodinol
  • HY-N18241
    Hibiscolactone A 74635-97-5
    Hibiscolactone A is a 2H-naphtho[2,3-b]furan-2-one derivative and a superoxide anion generation inhibitor, which can be isolated from the stems of Pachira aquatica. The IC50 value of Hibiscolactone A against fMLP (HY-P0224)-induced human neutrophil activity (inhibiting superoxide anion generation) is 63.22 μM.
    Hibiscolactone A
  • HY-N18243
    5-O-(E)-p-Coumaroylquinic acid methyl ester 1295570-97-6
    O-(E)-p-Coumaroylquinic acid methyl ester is a coumaric acid derivative found in the flowers of Vaccinium corymbosum. O-(E)-p-Coumaroylquinic acid methyl ester shows antioxidant effects and can be used for nutraceutical and functional food applications.
    5-O-(E)-p-Coumaroylquinic acid methyl ester
  • HY-N18251
    trans-β-Bergamotene 55123-21-2 98%
    trans-β-Bergamotene is a sesquiterpene hydrocarbon and antifungal agent found in the essential oil of Bixa orellana L. leaves. trans-β-Bergamotene possesses antiungal and anti-inflammatory properties. trans-β-Bergamotene can be used for the research of Candida albicans infection.
    trans-β-Bergamotene
Cat. No. Product Name / Synonyms Application Reactivity