Idesin

Cat. No.: HY-N18031: Data Sheet Handling Instructions
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Idesin is a compound found in the fruits of Idesia polycarpa. Idesin inhibits LPS (HY-D1056)-induced nitric oxide production with mild cytotoxicity.

For research use only. We do not sell to patients.

Idesin Chemical Structure

CAS No. : 20331-85-5

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Description

Idesin is a compound found in the fruits of Idesia polycarpa. Idesin inhibits LPS (HY-D1056)-induced nitric oxide production with mild cytotoxicity^[1].

In Vitro

Idesin (Compound 4) (1-100 μM; 25 h) significantly inhibits LPS (HY-D1056)-induced NO production in BV2 microglial cells, with mild cytotoxicity at 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	BV2 mouse microglial cells (LPS-stimulated)
Concentration:	1 μM, 10 μM, 100 μM
Incubation Time:	25 h total (1 h pre-treatment + 24 h co-incubation with LPS)
Result:	Reduced nitrite levels to 7.0 ± 0.1 μM and resulted in 87.2 ± 4.2% cell viability at 1 μM. Reduced nitrite levels to 5.5 ± 0.3 μM and resulted in 97.6 ± 6.3% cell viability at 10 μM. Reduced nitrite levels to 4.9 ± 0.5 μM and resulted in 90.7 ± 6.8% cell viability at 100 μM.

Molecular Weight

302.28

Formula

C₁₃H₁₈O₈

CAS No.

20331-85-5

SMILES

OCC(C=CC=C1O)=C1O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kim SH, et al. Inhibitory activity of phenolic glycosides from the fruits of Idesia polycarpa on lipopolysaccharide-induced nitric oxide production in BV2 microglia. Planta Med. 2007;73(2):167-169. [Content Brief]

Idesin Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Idesin20331-85-5NO SynthaseNitric oxide synthasesNOSnitric oxideIdesia polycarpamicrogliaBV2 microglial cellslipopolysaccharideInhibitorinhibitorinhibit

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