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Cat. No.: HY-N18235

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(1Z)-Atractylodinol

(1Z)-Atractylodinol, an acetylenes compound, is a weak 5-lipoxygenase (5-LOX) inhibitor with an IC₅₀ of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases.

For research use only. We do not sell to patients.

CAS No.: 362673-12-9
Formula: C₁₃H₁₀O₂
Molecular Weight:198.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

(1Z)-Atractylodinol Chemical Structure

CAS No.: 362673-12-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

(1Z)-Atractylodinol, an acetylenes compound, is a weak 5-lipoxygenase (5-LOX) inhibitor with an IC₅₀ of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases^[1].

IC₅₀ & Target

5-LOX

117.8 μM (IC₅₀)

All Lipoxygenase Isoforms :

In Vitro

(1Z)-Atractylodinol exerts weak inhibitory effects on 5-LOX with an IC₅₀ of 117.8 μM, and shows no inhibitory activity against COX-1 with an IC₅₀ greater than 200 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 362673-12-9
Molecular Weight 198.22
Formula C₁₃H₁₀O₂
SMILES

OC/C=C/C#CC#C/C=C\C1=CC=CO1
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Resch M, et al. Further phenols and polyacetylenes from the rhizomes of Atractylodes lancea and their anti-inflammatory activity. Planta Med. 2001 Jul;67(5):437-42. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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