2. Membrane Transporter/Ion Channel Apoptosis
  3. CRM1 PANoptosis
  4. Selinexor

Selinexor (KPT-330) is an analog of KPT-185 (HY-15611). Selinexor is an orally active, selective CRM1 inhibitor that inhibits tumor growth by inducing PANoptosis.

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CAS 番号 : 1393477-72-9

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カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Other Forms of Selinexor:

Selinexor 関連抗体

Top Publications Citing Use of Products

    Selinexor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Apr 12:116948.  [Abstract]

    From the above animal model, the tumors were isolated and examined by immunohistochemistry and quantified by ImageJ to detect cleaved caspase3 protein expression in CTR-KD and HCG11-KD tumors treated with Selinexor (10 mg/kg, twice per week) or PBS.

    Selinexor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Apr 12:116948.  [Abstract]

    Western blotting of PARP, cleaved PARP and cleaved caspase 3 in CTR-KD and XPO1-KD ARD cells treated with Selinexor (0.25 μM, 12 h).

    Selinexor purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Apr 12:116948.  [Abstract]

    Apoptosis rates of CTR-KD and XPO1-KD ARD cells treated with Selinexor (0.25 μM, 48 h).

    Selinexor purchased from MedChemExpress. Usage Cited in: Leukemia. 2023 Jun;37(6):1336-1348.  [Abstract]

    Percent apoptotic cells following KO of mtNPM1 and treatment with Selinexor (KPT-330, 30-1000 nM) at the indicated concentrations for 48 hours.

    Selinexor purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2023 Jul 3;19(11):3412-3427.

    HCCLM3 cells were treated with or without TNF-α and Selinexor (1 mM, 72 hours) followed by STAT3 co-immunoprecipitation assay.

    • 生物活性

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    製品説明

    Selinexor (KPT-330) is an analog of KPT-185 (HY-15611). Selinexor is an orally active, selective CRM1 inhibitor that inhibits tumor growth by inducing PANoptosis[1][2][3].

    IC50 & Target

    CRM1
    Cellular Effect
    Cell Line Type Value Description References
    HEK-293T IC50
    0.73 μM
    Compound: KPT-330
    Cytotoxicity against HEK293T cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
    Cytotoxicity against HEK293T cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
    		[PMID: 38105606]
    HPBALL IC50
    34 nM
    Compound: KPT-330
    Antiproliferative activity against human HPBALL cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human HPBALL cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay
    		[PMID: 38105606]
    HeLa IC50
    0.43 μM
    Compound: KPT-330
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
    Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
    		[PMID: 38105606]
    Jurkat EC50
    17 nM
    Compound: 1; KPT-330
    Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay
    Cytotoxicity against human Jurkat cells incubated for 24 hrs by celltiter glo assay
    		[PMID: 39005064]
    Jurkat IC50
    34 nM
    Compound: KPT-330
    Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay
    		[PMID: 38105606]
    KOPTK1 IC50
    34 nM
    Compound: KPT-330
    Antiproliferative activity against human KOPT-K1 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human KOPT-K1 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay
    		[PMID: 38105606]
    MOLT-4 IC50
    34 nM
    Compound: KPT-330
    Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay
    Antiproliferative activity against human MOLT-4 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter Glo assay
    		[PMID: 38105606]
    NSCLC IC50
    25 nM
    Compound: 2; KPT-330
    Antitumor activity against human NSCLC cells
    Antitumor activity against human NSCLC cells
    		[PMID: 34669417]
    体外実験

    As the clinical candidate analog of KPT-185, KPT-330 exhibits similar effects on the viability of T-ALL cells and elicits rapid apoptotic response. KPT-330 also reduces cell growth in MOLT-4, Jurkat, HBP-ALL, KOPTK-1, SKW-3, and DND-41 cell lines, with IC50 values of 34-203 nM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Selinexor 関連抗体
    体内実験

    Selinexor (KPT-330) dramatically suppresses the growth of T-ALL cells (MOLT-4) and AML cells (MV4–11) in vivo, with little toxicity to normal haematopoietic cells[1].
    In SCID mice with diffuse human MM bone lesions, KPT-330 inhibits MM-induced bone lysis and prolongs survival. Moreover, KPT-330 directly impairs osteoclastogenesis and bone resorption by blocking RANKL-induced NF-κB and NFATc1, with minimal impact on osteoblasts and BMSCs[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    443.31

    分子式

    C17H11F6N7O
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O=C(NNC1=NC=CN=C1)/C=C\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (225.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2558 mL 11.2788 mL 22.5576 mL
    5 mM 0.4512 mL 2.2558 mL 4.5115 mL
    10 mM 0.2256 mL 1.1279 mL 2.2558 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    • Protocol 2

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (4.69 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    In Vivo Dissolution Calculator
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    Please enter your animal formula composition:
    %
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.85%

    COA (251 KB) HNMR (276 KB) RP-HPLC (208 KB) LCMS (264 KB) Elemental Analysis Report (108 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.2558 mL 11.2788 mL 22.5576 mL 56.3939 mL
    5 mM 0.4512 mL 2.2558 mL 4.5115 mL 11.2788 mL
    10 mM 0.2256 mL 1.1279 mL 2.2558 mL 5.6394 mL
    15 mM 0.1504 mL 0.7519 mL 1.5038 mL 3.7596 mL
    20 mM 0.1128 mL 0.5639 mL 1.1279 mL 2.8197 mL
    25 mM 0.0902 mL 0.4512 mL 0.9023 mL 2.2558 mL
    30 mM 0.0752 mL 0.3760 mL 0.7519 mL 1.8798 mL
    40 mM 0.0564 mL 0.2820 mL 0.5639 mL 1.4098 mL
    50 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1279 mL
    60 mM 0.0376 mL 0.1880 mL 0.3760 mL 0.9399 mL
    80 mM 0.0282 mL 0.1410 mL 0.2820 mL 0.7049 mL
    100 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5639 mL
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    Selinexor Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Selinexor1393477-72-9KPT-330KPT330KPT 330CRM1PANoptosisChromosomal Maintenance 1Exportin 1XPO1Inhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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