L-type calcium channel Antagonist

L-type calcium channel Antagonists (23):

Cat. No.	Nombre del producto	Efecto	Pureza

HY-B0317

Amlodipine	Antagonist	99.87%
Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.

HY-137203

(+)-Niguldipine	Antagonist
(+)-Niguldipine is a potent dual inhibitor targeting L-type Ca²⁺ channels (K_i=85 pM) and α₁-adrenoceptor (K_i=52 pM). (+)-Niguldipine is promising for research of hypertension and cardiovascular diseases.

HY-14656

Diltiazem hydrochloride	Antagonist	99.47%
Diltiazem hydrochloride is a Ca²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

HY-B1655

Fluspirilene	Antagonist	99.66%
Fluspirilene is a non-competitive antagonist of L-type calcium channels with an IC₅₀ of 0.03 μM. Fluspirileneis a long-acting injectable depot antipsychotic agent used for schizophrenia.

HY-B0317B

Amlodipine besylate	Antagonist	99.72%
Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer.

HY-B0768A

Lomerizine dihydrochloride	Antagonist	99.95%
Lomerizine dihydrochloride is an antagonist of L- and T-type voltagegated calcium channels.

HY-134542

CaV1.3 antagonist-1	Antagonist	98.38%
CaV1.3 antagonist-1 is a potent and highly selective Ca_V1.3 L-type calcium channel (LTCC) antagonist with an IC₅₀ of 1.7 μM. CaV1.3 antagonist-1 inhibits Ca_V1.3 LTCC >600-fold more potently than Ca_V1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research.

HY-17611

Etripamil	Antagonist	98.10%
Etripamil (MSP-2017) is a short-acting, L-type calcium-channel antagonist. Etripamil inhibits calcium influx through slow calcium channels, thereby slowing AV node conduction and prolonging the AV node refractory period. Etripamil increases heart rate and decreases systolic blood pressure. Etripamil can be used in the study of paroxysmal supraventricular tachycardia (PSVT).

HY-112723

Apinocaltamide	Antagonist	99.83%
Apinocaltamide (ACT-709478) is a potent, selective, orally active, and brain penetrating T-type calcium channel blocker. ACT-709478 is used in the research of generalized epilepsies.

HY-107322

Barnidipine hydrochloride	Antagonist	99.94%
Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [³H] initrendipine binding sites (K_i = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance.

HY-B0317A

Amlodipine maleate	Antagonist	99.87%
Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.

HY-B0549A

Flavoxate hydrochloride	Antagonist	99.70%
Flavoxate hydrochloride (Rec-7-0040; DW61) is an orally active L-type Ca²⁺ channel inhibitor and antispasmodic. Flavoxate hydrochloride inhibits cyclic adenosine monophosphate production by blocking voltage-dependent inward Ba²⁺ currents, regulating the brainstem micturition center, and stimulating G protein-coupled receptors. Consequently, Flavoxate hydrochloride induces relaxation of bladder smooth muscle and inhibits isovolumetric rhythmic contractions. Flavoxate hydrochloride effectively increases bladder capacity and alleviates symptoms of urgent urination frequency and pollakiuria caused by overactive bladder. Flavoxate hydrochloride can be used in research on overactive bladder and related voiding dysfunctions.

HY-136909

SR33805	Antagonist	99.78%
SR33805 is a potent Ca²⁺ channel antagonist, with EC₅₀s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca²⁺ channels. SR33805 can be used for the research of acute or chronic failing hearts.

HY-B0265A

(R)-Nimodipine	Antagonist	99.87%
(R)-Nimodipine ((R)-BAY-e 9736) is an orally active, blood-brain barrier-permeable L-type calcium channel blocker with an IC₅₀ of 5 nM. (R)-Nimodipine inhibits corticosterone release by blocking calcium channels on the hypothalamic-pituitary-adrenal axis, thereby reversing immobilization stress-induced memory impairment and behavioral abnormalities. (R)-Nimodipine is widely used in studies related to aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related degenerative neurological diseases, and alcohol intoxication.

HY-108974

Drotaverine hydrochloride	Antagonist	99.65%
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.

HY-107322A

Barnidipine	Antagonist
Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [³H] initrendipine binding sites (K_i = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance.

HY-107322S

Barnidipine-d₅ hydrochloride	Antagonist	98.9%
Barnidipine-d₅ (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors.Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action.

HY-B0317AS

Amlodipine-d₄ maleate	Antagonist	98.19%
Amlodipine-d₄ (maleate) is the deuterium labeled Amlodipine maleate. Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.

HY-B0317C

Amlodipine mesylate	Antagonist
Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer.

HY-15553B

Mibefradil dihydrochloride hydrate	Antagonist
Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) is a effectively long-acting calcium channel antagonist, used as an antihypertensive agent. Mibefradil dihydrochloride hydrate acts via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels.

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