1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. SR33805

SR33805 

Cat. No.: HY-136909 Purity: 99.04%
Handling Instructions

SR33805 is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca2+ channels. SR33805 can be used for the research of acute or chronic failing hearts.

For research use only. We do not sell to patients.

SR33805 Chemical Structure

SR33805 Chemical Structure

CAS No. : 121345-64-0

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5 mg USD 180 In-stock
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10 mg USD 300 In-stock
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50 mg USD 850 In-stock
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100 mg USD 1300 In-stock
Estimated Time of Arrival: December 31
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Description

SR33805 is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca2+ channels. SR33805 can be used for the research of acute or chronic failing hearts[1][2].

IC50 & Target[1]

L-type calcium channel

4.1 nM (EC50, in depolarized conditions)

L-type calcium channel

33 nM (EC50, in polarized conditions)

In Vitro

SR33805 (0.01-10 µM; 3 d) inhibits growth factor-induced proliferation of SMC (0.2050<0.46 µM) in a dose-dependent manner[3].
SR33805 (10 µM; 10 min) restores the myocardial infarction (MI)-altered cell shortening without affecting the Ca2+ transient amplitude[2].
SR33805 (10 µM) decreases the activity of recombinant PKA[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Smooth muscle cells (SMC)
Concentration: 0.01, 0.1, 1, 10 µM
Incubation Time: 3 days
Result: Inhibited in a dose-dependent manner FCS-, bFGF and PDGF-induced proliferation of porcine SMC with IC50s of 0.26±0.08, 0.46±0.1 and 0.20±0.04 µM, respectively.
In Vivo

SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats[2].
SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (5 weeks) are subjected to coronary artery ligature[2]
Dosage: 0.2, 2, 20 mg/kg
Administration: A single i.p. injection
Result: Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg.
Did not affect other contractile parameters.
Molecular Weight

564.74

Formula

C₃₂H₄₀N₂O₅S

CAS No.

121345-64-0

SMILES

O=S(C1=CC=C(OCCCN(C)CCC2=CC=C(OC)C(OC)=C2)C=C1)(C3=C(C(C)C)N(C)C4=C3C=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

SR33805SR 33805SR-33805Calcium ChannelCa2+ channelsCa channelsCa2+channeldepolarizedpolarizedL-typeacutechronicfailingheartsInhibitorinhibitorinhibit

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