1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. CaV1.3 antagonist-1

CaV1.3 antagonist-1 

Cat. No.: HY-134542
Handling Instructions

CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research.

For research use only. We do not sell to patients.

CaV1.3 antagonist-1 Chemical Structure

CaV1.3 antagonist-1 Chemical Structure

CAS No. : 1391385-57-1

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Description

CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1].

IC50 & Target[1]

CaV1.3

1.7 μM (IC50)

In Vitro

CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

334.80

Formula

C₁₇H₁₉ClN₂O₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CaV1.3 antagonist-1
Cat. No.:
HY-134542
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