CaV1.3 antagonist-1
Based on 1 Customer Validation
CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research.
For research use only. We do not sell to patients.
- Purity: 98.38%
- CAS No.: 1391385-57-1
- Formula: C17H19ClN2O3
- Molecular Weight:334.80
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Calcium Channel Isoforms
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Biological Activity
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CaV1.3 1.7 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
>100 μM
Compound: 6, BPN-4689
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Antagonist activity at rabbit CaV1.2alpha1C transfected in HEK293 cells by FLIPR assay
Antagonist activity at rabbit CaV1.2alpha1C transfected in HEK293 cells by FLIPR assay
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[PMID: 23651412] |
| HEK293 | IC50 |
6.3 μM
Compound: 6, BPN-4689
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Antagonist activity at rat CaV1.3alpha1D transfected in HEK293 cells by FLIPR assay
Antagonist activity at rat CaV1.3alpha1D transfected in HEK293 cells by FLIPR assay
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[PMID: 23651412] |
CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1391385-57-1
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Appearance Solid
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Molecular Weight 334.80
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Formula C17H19ClN2O3
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Color White to light yellow
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SMILES
O=C1N(C2CCCC2)C(CC(N1CCC3=CC=CC(Cl)=C3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (298.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9869 mL | 14.9343 mL | 29.8686 mL | 74.6714 mL |
| 5 mM | 0.5974 mL | 2.9869 mL | 5.9737 mL | 14.9343 mL | |
| 10 mM | 0.2987 mL | 1.4934 mL | 2.9869 mL | 7.4671 mL | |
| 15 mM | 0.1991 mL | 0.9956 mL | 1.9912 mL | 4.9781 mL | |
| 20 mM | 0.1493 mL | 0.7467 mL | 1.4934 mL | 3.7336 mL | |
| 25 mM | 0.1195 mL | 0.5974 mL | 1.1947 mL | 2.9869 mL | |
| 30 mM | 0.0996 mL | 0.4978 mL | 0.9956 mL | 2.4890 mL | |
| 40 mM | 0.0747 mL | 0.3734 mL | 0.7467 mL | 1.8668 mL | |
| 50 mM | 0.0597 mL | 0.2987 mL | 0.5974 mL | 1.4934 mL | |
| 60 mM | 0.0498 mL | 0.2489 mL | 0.4978 mL | 1.2445 mL | |
| 80 mM | 0.0373 mL | 0.1867 mL | 0.3734 mL | 0.9334 mL | |
| 100 mM | 0.0299 mL | 0.1493 mL | 0.2987 mL | 0.7467 mL |
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