Mibefradil dihydrochloride hydrate
Based on 14 publication(s) in Google Scholar
Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) is a effectively long-acting calcium channel antagonist, used as an antihypertensive agent. Mibefradil dihydrochloride hydrate acts via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels.
For research use only. We do not sell to patients.
- CAS No.: 1049728-52-0
- Formula: C29H42Cl2FN3O4
- Molecular Weight:586.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Mibefradil dihydrochloride hydrate
More- ACS Nano. 2024 Nov 12;18(45):31451-31465. [Abstract]
- Neuron. 2026 Mar 27:S0896-6273(26)00126-1. [Abstract]
- Small. 2024 Nov;20(46):e2403381. [Abstract]
- Br J Pharmacol. 2021 Jan;178(2):346-362. [Abstract]
- PLoS Biol. 2024 Mar 25;22(3):e3002565. [Abstract]
- Eur J Pharmacol. 2021 Feb 5:892:173782. [Abstract]
- Front Pharmacol. 2022 Feb 23;13:816133. [Abstract]
- Mediators Inflamm. 2020 Nov 10:2020:3691701. [Abstract]
- J Cell Physiol. 2021 Sep;236(9):6548-6558. [Abstract]
- Theriogenology. 2021 Jan 1:159:140-146. [Abstract]
- Biochem Biophys Res Commun. 2025 Sep 19:785:152676. [Abstract]
- Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868. [Abstract]
- Biocell. 2026 Jan 23.
- Res Sq. 2024 Jun 11.
All Calcium Channel Isoforms
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Biological Activity
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L-type calcium channel |
Mibefradil inhibits reversibly the T- and L-type currents with IC50 values of 2.7 and 18.6 μM, respectively[2].
Mibefradil (20 µM) reduces the amplitude of excitatory junction potentials (by 37±10 %), slows the rate of repolarisation (by 44±16 %) and causes a significant membrane potential depolarisation (from -83±1 mV to -71±5 mV)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1049728-52-0
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Molecular Weight 586.57
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Formula C29H42Cl2FN3O4
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SMILES
[H]O[H].O=C(O[C@@]1(CCN(CCCC2=NC3=CC=CC=C3N2)C)[C@@H](C(C)C)C4=C(C=C(F)C=C4)CC1)COC.[H]Cl.[H]Cl
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Synonyms
Ro 40-5967 dihydrochloride hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (14)
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Journal Impact Factor
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Most Recent
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ACS Nano
Single-Molecule-Based, Label-Free Monitoring of Molecular Glue Efficacies for Promoting Protein-Protein Interactions Using YaxAB Nanopores. [Abstract]2024 Nov 12;18(45):31451-31465. PMID: 39482865 -
Neuron
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nicotine-withdrawal-induced anxiety. [Abstract]2026 Mar 27:S0896-6273(26)00126-1. PMID: 41903536 -
Small
2024 Nov;20(46):e2403381. PMID: 39126240 -
Br J Pharmacol
Small intestinal glucose and sodium absorption through calcium-induced calcium release and store-operated Ca2+ entry mechanisms. [Abstract]2021 Jan;178(2):346-362. PMID: 33080043 -
PLoS Biol
The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. [Abstract]2024 Mar 25;22(3):e3002565. PMID: 38527087 -
Eur J Pharmacol
T-type calcium channels blockers inhibit HSV-2 infection at the late stage of genome replication. [Abstract]2021 Feb 5:892:173782. PMID: 33279521 -
Front Pharmacol
Ca2+-Permeable Channels/Ca2+ Signaling in the Regulation of Ileal Na+/Gln Co-Transport in Mice. [Abstract]2022 Feb 23;13:816133. PMID: 35281933 -
Mediators Inflamm
Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury. [Abstract]2020 Nov 10:2020:3691701. PMID: 33223955 -
J Cell Physiol
Effects of various calcium transporters on mitochondrial Ca2+ changes and oocyte maturation. [Abstract]2021 Sep;236(9):6548-6558. PMID: 33704771 -
Theriogenology
Lysine acetylation participates in boar spermatozoa motility and acrosome status regulation under different glucose conditions. [Abstract]2021 Jan 1:159:140-146. PMID: 33152539 -
Biochem Biophys Res Commun
Glucose transports in the ileum: mechanism, regulation and physiological role of ileal glucose absorption. [Abstract]2025 Sep 19:785:152676. PMID: 41005286 -
Biochem Biophys Res Commun
Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]2020 Feb 19;522(4):862-868. PMID: 31806372 -
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Purity & Documentation
References
[1]. Martin RL, Lee JH, Cribbs LL, Perez-Reyes E, Hanck DA. Mibefradil block of cloned T-type calcium channels. J Pharmacol Exp Ther. 2000 Oct;295(1):302-8. [Content Brief]
[2]. Mehrke G, et al. The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J Pharmacol Exp Ther. 1994 Dec;271(3):1483-8. [Content Brief]
[3]. Brain KL, et al. The sources and sequestration of Ca(2+) contributing to neuroeffector Ca(2+) transients in the mouse vas deferens. J Physiol. 2003 Dec 1;553(Pt 2):627-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mibefradil dihydrochloride hydrate Related Classifications
HY-15553B Related Classifications
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