1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. Barnidipine hydrochloride

Barnidipine hydrochloride (Synonyms: Mepirodipine (hydrochloride); YM-09730-5)

Cat. No.: HY-107322 Purity: 98.77%
Handling Instructions

Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive drug and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action.

For research use only. We do not sell to patients.

Barnidipine hydrochloride Chemical Structure

Barnidipine hydrochloride Chemical Structure

CAS No. : 104757-53-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 75 In-stock
Estimated Time of Arrival: December 31
100 mg USD 110 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors[1]. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive drug and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action[2].

IC50 & Target

Ki: 0.21 nmol/l ([3H] initrendipine)[1]

Molecular Weight

528.00

Formula

C₂₇H₃₀ClN₃O₆

CAS No.

104757-53-1

SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)[[email protected]@H]1C2=CC([N+]([O-])=O)=CC=C2)O[[email protected]@H]3CN(CC4=CC=CC=C4)CC3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (473.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8939 mL 9.4697 mL 18.9394 mL
5 mM 0.3788 mL 1.8939 mL 3.7879 mL
10 mM 0.1894 mL 0.9470 mL 1.8939 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product name:
Barnidipine hydrochloride
Cat. No.:
HY-107322
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