Art. -Nr.: HY-107322

Barnidipine hydrochloride

Name: Barnidipine hydrochloride
Brand: MedChemExpress
SKU: HY-107322
Price: 32.00 USD
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(Synonyms: Mepirodipine hydrochloride; YM-09730-5)

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Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [³H] initrendipine binding sites (K_i = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance.

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Reinheit : 99.94%
CAS. Nr.: 104757-53-1
Formel: C₂₇H₃₀ClN₃O₆
Molecular Weight:528.00

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Barnidipine hydrochloride Chemical Structure

CAS. Nr.: 104757-53-1

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

L-type calcium channel

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In Vivo

Barnidipine hydrochloride (53 mg/kg; Feed administration; 3 weeks) reduces the level of platelet-derived growth factor B chain mRNA, and has a effect on lowering blood pressure in spontaneously hypertensive rats^[2].
Pharmacokinetic analysis in rats and dogs after intravenous administration^[3]

Parameters	Rat	Dog
Dose (mg/kg)	0.05	0.05
C₀ (ng/ml)	57.9	40.2
t_1/2α (h)	0.06	0.3
t_1/2β (h)	0.6	4.1
AUC (ng·h/ml)	17.7	30.2
Cl_p (l/h/kg)	2.8	1.7
CL_b (l/h/kg)	5.2	3.3
V₁ (l/kg)	0.9	1.3
V₂ (l/kg)	1.1	2.8
V_dss (l/kg)	2.0	4.1
K_el (h^-1)	3.3	1.3
K₁₂ (h^-1)	4.9	0.6
K₂₁ (h^-1)	3.9	0.3

Pharmacokinetic analysis in rats after oral administration^[3]

Parameters	0.4 (mg/kg)	1.0 (mg/kg)	3.0 (mg/kg)
t_max (h)	0.3	0.3	0.3
C_max (ng/ml)	19.0	75.8	292.6
AUC_0-∞ (ng·h/ml)	15.2	47.4	191.1
t_1/2β (h)	1.0	1.7	1.0
F (%)	11	13	18

Pharmacokinetic analysis in dogs after oral administration^[3]

Parameters	0.2 (mg/kg)	0.4 (mg/kg)	1.0 (mg/kg)
t_max (h)	0.3	0.4	0.3
C_max (ng/ml)	4.6	9.7	44.0
AUC_0-∞ (ng·h/ml)	6.8	16.2	60.2
t_1/2β (h)	4.3	3.6	3.6
F (%)	6	7	9

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SHR aged 13 weeks old^[2]
Dosage:

0.6 mg/g of food (average dose: 53 mg/kg of body mass/day)
Administration:

Feed administration; 3 weeks
Result:

Reduced systolic blood pressure steadily after week 1 of therapy.
Did not change renal histology after week 3 of therapy.
Significantly reduced the level of expression of PDGF B-chain mRNA in glomeruli.
Significantly reduced the excretion of urinary protein.

Related Protocols :

RNA extraction experimental

Chemical Information

CAS. Nr. 104757-53-1
Appearance Solid
Molecular Weight 528.00
Formel C₂₇H₃₀ClN₃O₆
Color Light yellow to yellow
SMILES

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)O[C@@H]3CN(CC4=CC=CC=C4)CC3.[H]Cl
Synonyms

Mepirodipine hydrochloride; YM-09730-5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 233.33 mg/mL (441.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8939 mL

9.4697 mL

18.9394 mL

5 mM

0.3788 mL

1.8939 mL

3.7879 mL

10 mM

0.1894 mL

0.9470 mL

1.8939 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8. [Content Brief]

[2]. Hashimoto M, et al. Treatment with a Ca(2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Am J Nephrol. 1999;19(5):615-21. [Content Brief]

[3]. Teramura T, et al. Pharmacokinetics of barnidipine hydrochloride, a new dihydropyridine calcium channel blocker, in the rat, dog and human. Xenobiotica. 1995 Nov;25(11):1237-46. [Content Brief]

[4]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8939 mL	9.4697 mL	18.9394 mL	47.3485 mL
	5 mM	0.3788 mL	1.8939 mL	3.7879 mL	9.4697 mL
	10 mM	0.1894 mL	0.9470 mL	1.8939 mL	4.7348 mL
	15 mM	0.1263 mL	0.6313 mL	1.2626 mL	3.1566 mL
	20 mM	0.0947 mL	0.4735 mL	0.9470 mL	2.3674 mL
	25 mM	0.0758 mL	0.3788 mL	0.7576 mL	1.8939 mL
	30 mM	0.0631 mL	0.3157 mL	0.6313 mL	1.5783 mL
	40 mM	0.0473 mL	0.2367 mL	0.4735 mL	1.1837 mL
	50 mM	0.0379 mL	0.1894 mL	0.3788 mL	0.9470 mL
	60 mM	0.0316 mL	0.1578 mL	0.3157 mL	0.7891 mL
	80 mM	0.0237 mL	0.1184 mL	0.2367 mL	0.5919 mL
	100 mM	0.0189 mL	0.0947 mL	0.1894 mL	0.4735 mL

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Barnidipine hydrochloride

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