Barnidipine-d5 hydrochloride
Based on 1 Customer Validation
Barnidipine-d5 (hydrochloride) is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors.Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive agent and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 98.0%
- CAS No.: 2930289-02-2
- 화학식: C27H25D5ClN3O6
- 분자량:533.03
-
보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
All Calcium Channel Isoforms
More
Biological Activity
제품 설명
IC50 & Target
|
L-type calcium channel |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 2930289-02-2
-
Unlabeled CAS 104757-53-1
-
Appearance Solid
-
분자량 533.03
-
화학식 C27H25D5ClN3O6
-
Color Off-white to light yellow
-
SMILES
CC1=C([C@@H](C2=CC([N+]([O-])=O)=CC=C2)C(C(OC)=O)=C(N1)C)C(O[C@@H]3CN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])=O.Cl
-
Synonyms
Mepirodipine-d5 hydrochloride; YM-09730-5-d5 hydrochloride
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
In Vitro:
DMSO : 250 mg/mL (469.02 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (277 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8. [Content Brief]
[3]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8761 mL | 9.3803 mL | 18.7607 mL | 46.9017 mL |
| 5 mM | 0.3752 mL | 1.8761 mL | 3.7521 mL | 9.3803 mL | |
| 10 mM | 0.1876 mL | 0.9380 mL | 1.8761 mL | 4.6902 mL | |
| 15 mM | 0.1251 mL | 0.6254 mL | 1.2507 mL | 3.1268 mL | |
| 20 mM | 0.0938 mL | 0.4690 mL | 0.9380 mL | 2.3451 mL | |
| 25 mM | 0.0750 mL | 0.3752 mL | 0.7504 mL | 1.8761 mL | |
| 30 mM | 0.0625 mL | 0.3127 mL | 0.6254 mL | 1.5634 mL | |
| 40 mM | 0.0469 mL | 0.2345 mL | 0.4690 mL | 1.1725 mL | |
| 50 mM | 0.0375 mL | 0.1876 mL | 0.3752 mL | 0.9380 mL | |
| 60 mM | 0.0313 mL | 0.1563 mL | 0.3127 mL | 0.7817 mL | |
| 80 mM | 0.0235 mL | 0.1173 mL | 0.2345 mL | 0.5863 mL | |
| 100 mM | 0.0188 mL | 0.0938 mL | 0.1876 mL | 0.4690 mL |
Barnidipine-d5 hydrochloride Related Classifications
HY-107322S Related Classifications
Powered by Bioz