Barnidipine hydrochloride (Standard)  (Synonyms: Mepirodipine hydrochloride (Standard); YM-09730-5 (Standard))

Barnidipine hydrochloride (Standard) (Mepirodipine hydrochloride (Standard)) is the analytical standard of Barnidipine (hydrochloride) (HY-107322). This product is intended for research and analytical applications. Barnidipine (Mepirodipine) hydrochloride is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (K_i = 0.21 nmol/L, has selective action against CaA receptors. Barnidipine hydrochloride is an orally active antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance^[1][2][3][4].

Ki: 0.21 nmol/l ([³H] initrendipine)^[1]

528.00

C₂₇H₃₀ClN₃O₆

104757-53-1

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)O[C@@H]3CN(CC4=CC=CC=C4)CC3.[H]Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8.  [Content Brief]

  [2]. Hashimoto M, et al. Treatment with a Ca(2+) channel blocker, barnidipine, reduces platelet-derived growth factor B-chain mRNA in glomeruli of spontaneously hypertensive rats. Am J Nephrol. 1999;19(5):615-21.  [Content Brief]

  [3]. Teramura T, et al. Pharmacokinetics of barnidipine hydrochloride, a new dihydropyridine calcium channel blocker, in the rat, dog and human. Xenobiotica. 1995 Nov;25(11):1237-46.  [Content Brief]

  [4]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.  [Content Brief]